Effect of Silicon Oil on Retinal Electrical Functions Using Multifocal Electroretinogram

NCT07609628 | Recruiting DMC

• 1 other identifier: Rhegmatogenous Retinal Detatch
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Retinal detachment is one of the leading causes for permanent vision loss.Incidence of Rheugmatogenous Retinal Detachment (RRD) about 10.5 people per 100,000 population pars plana vitrectomy is the most popular and effective surgical options. Tamponade agents as silicone oils are used to restore intraocular volume and apply surface tension to the detached retinal surface Silicone oil (SO) is a liquid containing polymerized siloxane with organic side chains. It has a high thermal stability, is hydrophobic, and chemically inert. The use of silicone oils as intraocular tamponades dates from 1962.

Conditions

Rhegmatogenous Retinal Detachment

Outcome Measures

Primary Outcomes (2)

• Retinal Functions after vitrectomy

  Evaluation of the Function of the Eye Retina after Vitrectomy for all the participants

  1 Month to 3 Months

• Electroretinogram Examination after vitrectomy

  Electroretinogram examination which performed for all eyes after the vitrectomy as:When the light hits the eye, the photoreceptors (rods and cones) and other retinal cells generate small electrical impulses. The Electroretinogram captures and graphs these impulses to evaluate if these cells are functioning normally or not.

  1 Month to 3 Months

Study Arms (1)

Effect of Silicon Oil on Retinal Functions after Viterectomy

EXPERIMENTAL

About the 50 patients suffering from Rhegmatogenous Retinal Detatchment. All participants will undergo Viterectomy then the Retinal Functions will be evaluated by using Silicon oil tamponade recorded by Multi focal electroretinogram before and after the operation.

Device: Multi focal electroretinogram

Interventions

Multi focal electroretinogram DEVICE

to evaluat the effect of silicon oil on retinal function in the eyes that underwent Pars Plana Vitrectomy with Silicon oil tamponade for Rheugmatogenous Retinal Detachment. mfERG responses were recorded before and after Silicon oil removal .

Also known as: Silicon oil tamponade, Viterectomy

Effect of Silicon Oil on Retinal Functions after Viterectomy

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Patients with primary rhegmatogenous retinal detachment

You may not qualify if:

• Patients with history of previous intraocular surgery.
• Patients with combined traction-rhegmatogenous retinal detachment
• Patients with ocular disease as glaucoma ,degenerative myopia,age related macular degeneration
• Patients with poor fixation.
• Uncooperative patients.
• Patients with retinopathy.
• emulsified SO or complicated SO removal were excluded from this study

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Faculty of medicine

Minya, Minya Governorate, 61111, Egypt

RECRUITING

Study Officials

• Mahmoud Mohammed M. Genedy, Professor

  Department of Ophthalmology, fuculty of medicine,Minia University

  STUDY CHAIR

Central Study Contacts

Amany Nady Mohammed Mohammed, Resident

CONTACT

+201151849593; drmonmonnady92@gmail.com

Amr Abdelrahman, professor

CONTACT

+201093292792

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of Ophthalmology Department, Faculty of Medicine

Study Record Dates

• First Submitted: January 12, 2026
• First Posted: May 27, 2026
• Study Start: February 1, 2026
• Primary Completion: July 15, 2026
• Study Completion: August 1, 2026
• Last Updated: May 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)