Latent Tuberculosis Infection Screening Using QuantiFERON at Pre-Employment Assessment in Hospital Workers CHu Nice
Relevance of Systematic Latent Tuberculosis Infection Screening Using QuantiFERON at Pre-Employment Assessment in Hospital Workers: A Retrospective Study at the University Hospital of Nice
1 other identifier
observational
1,185
1 country
1
Brief Summary
This retrospective observational single-center study aims to evaluate the medical and occupational relevance of systematic screening for latent tuberculosis infection using QuantiFERON-TB Gold Plus during pre-employment occupational health assessment among hospital workers at the University Hospital of Nice. Data will be collected retrospectively from occupational health medical records, immunology laboratory results and, when necessary, data from specialized follow-up by the tuberculosis control center. The primary objective is to determine the proportion of positive QuantiFERON-TB Gold Plus tests at pre-employment screening. Secondary objectives are to identify factors associated with a positive test, to describe the practical consequences of screening, including chest X-ray, diagnosis of latent tuberculosis infection and initiation of preventive treatment, and to estimate the cost of systematic screening.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2026
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 20, 2026
CompletedFirst Posted
Study publicly available on registry
May 27, 2026
CompletedStudy Start
First participant enrolled
June 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 30, 2026
May 27, 2026
May 1, 2026
29 days
May 20, 2026
May 20, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Percentage of positive QuantiFERON-TB Gold Plus tests at pre-employment screening
Percentage of positive QuantiFERON-TB Gold Plus
At the inclusion
Secondary Outcomes (2)
Association between risk factors and positive QuantiFERON-TB Gold Plus test
At the inclusion
Percentage of workers with clinical follow-up after positive QuantiFERON-TB Gold Plus test
From the positive QuantiFERON-TB Gold Plus test to completion of specialist follow-up.
Study Arms (2)
Hospital workers with direct patient contact
Hospital workers without direct patient contact
Interventions
Retrospective analysis of QuantiFERON-TB Gold Plus results performed as part of routine pre-employment occupational health screening. No additional diagnostic test or intervention will be performed for the purpose of the study.
Eligibility Criteria
The study population consists of newly recruited hospital workers at the University Hospital of Nice who underwent pre-employment occupational health assessment and QuantiFERON-TB Gold Plus screening during the study period. The population includes medical, paramedical, medico-technical, administrative, technical, logistical, transport and support staff, with or without direct patient contact.
You may qualify if:
- Newly recruited hospital workers at the University Hospital of Nice.
- Workers who underwent pre-employment occupational health assessment during the study period.
- Workers who had a QuantiFERON-TB Gold Plus test performed as part of pre-employment screening.
You may not qualify if:
- Known history of active tuberculosis disease before employment.
- Previously known latent tuberculosis infection before employment.
- Incomplete or unusable occupational health records.
- Indeterminate QuantiFERON-TB Gold Plus results will be included in the descriptive analysis but excluded from comparative analyses of test positivity.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHU de NICE
Nice, Alpes Maritimes, 06000, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 20, 2026
First Posted
May 27, 2026
Study Start
June 1, 2026
Primary Completion (Estimated)
June 30, 2026
Study Completion (Estimated)
August 30, 2026
Last Updated
May 27, 2026
Record last verified: 2026-05