Electrolyte Beverage Combined With Polyethylene Glycol for Colonoscopy Bowel Preparation

NCT07608120 | Recruiting

• 1 other identifier: NFEC-2026-307
• Study Type: interventional
• Target: 405
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Participants undergoing elective colonoscopy will be randomly assigned to one of three bowel preparation regimens: PEG prepared with water only, PEG prepared with a low ratio of electrolyte beverage and water, or PEG prepared with a medium ratio of electrolyte beverage and water. The primary outcome is adequate bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes include bowel preparation completion rate, tolerability, adverse events, repeat colonoscopy rate, adenoma detection rate, and ingestion rhythm characteristics during bowel preparation. This study also aims to explore whether electrolyte beverage-assisted bowel preparation may improve bowel cleansing quality by influencing participants' ingestion rhythm and adherence during PEG intake.

Conditions

Colonoscopy; Bowel Preparation Solutions; Colorectal Cancer Screening

Outcome Measures

Primary Outcomes (1)

• Adequate Bowel Preparation Rate

  Adequate bowel preparation is defined as a total Boston Bowel Preparation Scale (BBPS) score ≥6 with each colonic segment score ≥2 during colonoscopy.

  At the time of colonoscopy on Day 1

Secondary Outcomes (3)

• Total Boston Bowel Preparation Scale Score

  At the time of colonoscopy on Day 1

• Bowel Preparation Completion Rate

  During bowel preparation within 1 hour before colonoscopy on Day 1

• Adverse Event Rate

  During bowel preparation within 1 hour before colonoscopy on Day 1

Study Arms (3)

Water Group

ACTIVE COMPARATOR

Participants receive polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy.

Other: PEG With Water

Low-dose Electrolyte Beverage Group

EXPERIMENTAL

Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy.

Other: PEG With Low-dose Electrolyte Beverage

Medium-dose Electrolyte Beverage Group

EXPERIMENTAL

Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy.

Other: PEG With Medium-dose Electrolyte Beverage

Interventions

PEG With Water OTHER

Polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy.

Water Group

PEG With Low-dose Electrolyte Beverage OTHER

Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy.

Low-dose Electrolyte Beverage Group

PEG With Medium-dose Electrolyte Beverage OTHER

Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy.

Medium-dose Electrolyte Beverage Group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18-75 years scheduled to undergo elective colonoscopy
• Meet the standard clinical indications for colonoscopy;
• Able to understand and comply with the bowel preparation procedure and complete oral polyethylene glycol (PEG) intake as required;
• Able to comply with study-related data collection and follow-up;
• Provide written informed consent voluntarily.

You may not qualify if:

• Previously diagnosed colorectal cancer, intestinal obstruction, or suspected intestinal obstruction;
• Active gastrointestinal bleeding or a definite history of gastrointestinal bleeding within the past 4 weeks (including melena, hematochezia, or hematemesis);
• Severe renal insufficiency, decompensated heart failure, significant electrolyte imbalance, or other conditions unsuitable for PEG bowel preparation;
• Known allergy to polyethylene glycol or components of the electrolyte beverage used in the study;
• Pregnant or breastfeeding women;
• Any other condition considered by the investigators to make the participant unsuitable for the study.

Sponsors & Collaborators

• Nanfang Hospital, Southern Medical University: lead

Study Sites (1)

Nanfang Hospital, Southern Medical University

Guangzhou, Guangdong, China

RECRUITING

MeSH Terms

Interventions

Water

Intervention Hierarchy (Ancestors)

Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Central Study Contacts

Aimin Li

CONTACT

+86 13580317630; lam0725@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 18, 2026
• First Posted: May 27, 2026
• Study Start: May 18, 2026
• Primary Completion (Estimated): January 31, 2027
• Study Completion (Estimated): May 31, 2027
• Last Updated: May 27, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)