Inflammatory Indices, Early Mortality, and ICU Stay in Geriatric PFN Patients

NCT07607886 | Active Not Recruiting

• 1 other identifier: GYEAH-PFN-RAR-2026-05
• Study Type: observational
• Target: 233
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observational cohort study aims to evaluate the association between preoperative and postoperative inflammatory indices and early postoperative outcomes in geriatric patients undergoing proximal femoral nailing (PFN) for intertrochanteric femur fractures. The primary outcome of the study is 30-day mortality, while the secondary outcome is intensive care unit (ICU) length of stay. Various inflammatory biomarkers derived from routine laboratory parameters, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), immune-inflammatory prognostic index (IPI), aggregate index of systemic inflammation (AIS), and RDW-to-albumin ratio (RAR), will be analyzed to investigate their prognostic value in the acute postoperative period. The study seeks to identify simple and readily accessible biomarkers that may contribute to early risk stratification and perioperative management in elderly hip fracture patients.

Conditions

Geriatric Anesthesia; Hip Fracture Surgeries; Intertrochanteric Femur Fracture

Keywords

Proximal Femoral Nailing; Inflammatory Indices; RDW-to-Albumin Ratio; Early Mortality; Intensive Care Unit; Geriatric Patients; Hip Fracture Surgery; RAR; PFN

Outcome Measures

Primary Outcomes (1)

• 30-Day Mortality

  Evaluation of all-cause mortality occurring within the first 30 postoperative days in geriatric patients undergoing proximal femoral nailing surgery.

  Within 30 days after surgery

Secondary Outcomes (1)

• Intensive Care Unit Length of Stay

  30 days

Study Arms (1)

Geriatric PFN Cohort

Geriatric patients aged 65 years and older who underwent proximal femoral nailing (PFN) surgery for intertrochanteric femur fractures and were retrospectively evaluated for inflammatory indices, 30-day mortality, and intensive care unit length of stay.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Geriatric patients aged 65 years and older who underwent proximal femoral nailing (PFN) surgery for intertrochanteric femur fractures at a tertiary referral center were retrospectively evaluated. The study population consisted of patients with available perioperative laboratory data, 30-day mortality information, and intensive care unit follow-up records.

You may qualify if:

• Patients aged 65 years and older
• Diagnosis of intertrochanteric femur fracture
• Undergoing proximal femoral nailing (PFN) surgery
• Availability of preoperative laboratory data
• Availability of early postoperative laboratory measurements
• Availability of 30-day mortality data
• Availability of intensive care unit admission and ICU length of stay data
• Complete electronic medical records

You may not qualify if:

• Patients with missing clinical or laboratory data
• Pathological fractures
• Multiple trauma patients
• Revision surgeries
• Presence of active infection or sepsis before surgery
• Hematologic diseases that could affect inflammatory indices
• Unavailable 30-day mortality or ICU data

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

University of Health Sciences Gazi Yaşargil Training and Research Hospital

Diyarbakır, Diyarbakır, Turkey (Türkiye)

Location

Study Officials

• selen topalel, MD

  Department of Anesthesiology and Reanimation, Gazi Yaşargil Training and Research Hospital, University of Health Sciences, Diyarbakır, Türkiye

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiologist

Study Record Dates

• First Submitted: May 12, 2026
• First Posted: May 26, 2026
• Study Start: January 1, 2021
• Primary Completion: June 15, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: May 28, 2026

Record last verified: 2026-05

Locations

TU (1)