Muscle Ultrasound for Sarcopenia Assessment in Kidney Transplant Recipients

NCT07607236 | Not Yet Recruiting

• 1 other identifier: 2026-304
• Study Type: observational
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

This is a single-center prospective observational study designed to evaluate the effectiveness of multimodal muscle ultrasound for the assessment of sarcopenia in kidney transplant recipients. Adult patients undergoing kidney transplantation will undergo both muscle ultrasound and bioelectrical impedance analysis (BIA) at predefined time points before and after transplantation. The primary objective is to evaluate the diagnostic performance of muscle ultrasound for sarcopenia assessment, including its correlation and agreement with BIA-derived skeletal muscle index (BIA-SMI), as well as its diagnostic accuracy. Secondary objectives include describing the longitudinal changes in sarcopenia prevalence and muscle-related parameters from the pre-transplant period to 1 year after transplantation. The study aims to provide evidence for a convenient, noninvasive, radiation-free, and reliable method for sarcopenia assessment in kidney transplant recipients.

Conditions

Sarcopenia; Muscle Wasting; Kidney Transplantation

Keywords

Muscle Ultrasound; Bioelectrical Impedance Analysis; BIA-SMI; Kidney Transplant Recipient; Muscle Mass; Frailty; Prospective Cohort

Outcome Measures

Primary Outcomes (1)

• Area under the receiver operating characteristic (ROC) curve of muscle ultrasound for detecting sarcopenia using BIA-derived skeletal muscle index (BIA-SMI) as the reference standard.

  Diagnostic performance of multimodal muscle ultrasound for sarcopenia assessment using BIA-derived skeletal muscle index (BIA-SMI) as the reference standard, including receiver operating characteristic (ROC) curve analysis and area under the curve (AUC).

  From baseline to 1 year after kidney transplantation

Secondary Outcomes (3)

• Change in Muscle Thickness Measured by Ultrasound

  From baseline to 1 year after kidney transplantation

• Change in Muscle Cross-Sectional Area Measured by Ultrasound

  From baseline to 1 year after kidney transplantation

• Change in Muscle Echogenicity Measured by Ultrasound

  From baseline to 1 year after kidney transplantation

Study Arms (1)

Kidney Transplant Recipients

Adult kidney transplant recipients undergoing prospective assessment of sarcopenia using multimodal muscle ultrasound and bioelectrical impedance analysis (BIA).

Diagnostic Test: Muscle Ultrasound

Interventions

Muscle Ultrasound DIAGNOSTIC_TEST

Multimodal muscle ultrasound assessment performed for evaluation of sarcopenia in kidney transplant recipients.

Kidney Transplant Recipients

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult kidney transplant recipients undergoing perioperative sarcopenia assessment at Sichuan Provincial People's Hospital.

You may qualify if:

• Adult patients aged 18 years or older
• Patients scheduled to undergo kidney transplantation
• Ability to undergo muscle ultrasound and bioelectrical impedance analysis (BIA)
• Ability to provide written informed consent

You may not qualify if:

• Patients with severe limb deformity or conditions preventing muscle ultrasound assessment
• Patients with implanted electronic devices contraindicating BIA assessment
• Inability to complete study assessments

Sponsors & Collaborators

• Sichuan Provincial People's Hospital: lead

Study Sites (1)

Sichuan Provincial People's Hospital

Chengdu, Sichuan, 610072, China

Location

MeSH Terms

Conditions

Sarcopenia; Muscular Atrophy; Frailty

Condition Hierarchy (Ancestors)

Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Pathologic Processes

Central Study Contacts

Yifu Hou, MD, PhD

CONTACT

+86-18980732072; houyifu0726@foxmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Chief Physician

Study Record Dates

• First Submitted: May 11, 2026
• First Posted: May 26, 2026
• Study Start: May 30, 2026
• Primary Completion (Estimated): August 30, 2027
• Study Completion (Estimated): January 30, 2028
• Last Updated: May 26, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)