Human Tendon Tissue Collection

NCT07606092 | Not Yet Recruiting

• 1 other identifier: 368295
• Study Type: observational
• Target: 400
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this study is to improve understanding of tendon health and disease by using surplus tendon tissue that is routinely removed during planned orthopaedic surgeries in adults. The main questions it aims to answer are: \- What can tendon tissue and tendon cells tell us about how healthy and diseased tendons function? Participants will not undergo any extra procedures. Instead, researchers will use only tissue that is already being removed as part of normal surgical care and would otherwise be discarded. Participants will:

• Be asked for permission (consent) before their surgery to donate any surplus tendon tissue.
• Have a small piece of tendon tissue (normally waste material) collected during their planned operation.
• Allow the research team to access some non-identifiable medical information (such as age, reason for surgery, and relevant medical history) to help interpret research findings. What the researchers will do with the donated tissue:
• Isolate different types of human tendon cells.
• Build advanced laboratory cellular models to study how tendon diseases develop.
• Analyse whole tendon tissue sections to understand cell types, tissue organisation, and disease-related changes. This study does not involve testing treatments, and it does not change any aspect of a participant's clinical care. Although there is no direct benefit to participants, the donated tissue may help researchers develop better ways to study tendon injuries and improve future treatment options for tendon disease.

Conditions

Tendinopathy; Achilles Tendon Surgery; Musculoskeletal Diseases or Conditions; ACL Surgery

Keywords

Tendon tissue collection

Outcome Measures

Primary Outcomes (1)

• Obtain sufficient tendon tissue samples.

  The main outcome of this project is to obtain sufficient tendon tissue to isolate different human tendon cells and perform tissue analysis.

  Perioperative to immediate post-collection laboratory processing (within 24 hours).

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled to undergo orthopaedic lower limb surgery at the Royal London, Whipps Cross University Hospital and the Barts Health Orthopaedic Centre in Newham.

You may qualify if:

• years or older
• Scheduled to undergo orthopaedic lower limb surgery that involve tendon tissue waste
• Have provided informed consent to take part in the study

You may not qualify if:

• Under the age of 18
• Unable or unwilling to give informed consent (including those with limited English proficiency)
• Cases where tendon tissue is required for clinical care and therefore not surplus.

Sponsors & Collaborators

• Queen Mary University of London: lead

Biospecimen

Retention: SAMPLES WITH DNA

Fresh human tendon tissue that is surplus to clinical need and routinely removed during planned orthopaedic surgeries.

MeSH Terms

Conditions

Tendinopathy; Musculoskeletal Diseases

Condition Hierarchy (Ancestors)

Muscular Diseases; Tendon Injuries; Wounds and Injuries

Study Officials

• Hazel Screen, Professor, PhD

  Queen Mary University of London

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mays Jawad, PhD

CONTACT

020 7882 7275/6574; research.governance@qmul.ac.uk

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 1, 2026
• First Posted: May 26, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): June 1, 2031
• Study Completion (Estimated): June 1, 2031
• Last Updated: May 26, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share