Isoinertial Training in Patients With COPD

NCT07605117 | Not Yet Recruiting DMC

• 1 other identifier: DCTAFD24 23
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 2

Brief Summary

Isoinertial training is emerging as a potentially effective strategy to improve strength and functionality in older people diagnosed with chronic obstructive pulmonary disease (COPD), due to its influence on muscle mass and neuromuscular efficiency. COPD is characterized by systemic alterations, including peripheral muscle dysfunction; which contributes to patient functional limitation, and reduces patients' quality of life. Isoinertial training may improve the physiological response to effort, and also promote functional performance in this population. Hence, the aim of this study is to evaluate the effect of an isoinertial training program on muscle strength and functional capacity in patients with COPD during an 8-week intervention.

Conditions

COPD (Chronic Obstructive Pulmonary Disease)

Keywords

Muscle Strength; Functional Capacity; Pulmonary Rehabilitation; Interventional study; Adults; Exercise; Flywheel training; Lung Disease

Outcome Measures

Primary Outcomes (5)

• Change in upper limb muscle strength using the Hand Grip Test (HGT)

  Manual grip strength will be evaluated by dynamometry, as an indicator of peripheral muscle strength in patients with COPD.

  Baseline and 8-week follow-up

• Change in functional capacity by 6-minute walk test (6MWT)

  The distance covered for 6 minutes will be evaluated as an indicator of exercise tolerance and functional capacity.

  Baseline and 8-week follow-up

• Lower limb functional performance

  The number of repetitions performed in 30 seconds will be recorded as an indicator of functional strength-endurance in the lower limbs

  Baseline and 8-week follow-up

• Change in functional mobility using the Timed Up and Go Test (TUG)

  The time needed to get up from a chair, walk, turn and sit down again will be measured, as an indicator of mobility and functional risk.

  Baseline and 8-week follow-up

• Change in muscle quality index (MQI)

  Muscle quality will be estimated using the MQI, which evaluates the muscle power of the lower limbs considering leg length, body mass, gravitational acceleration and time required to complete 10 sit-to-stand repetitions

  Baseline and 8-week follow-up

Secondary Outcomes (6)

• Change in functional performance using 5 Times Sit-to-Stand Test (5STS)

  Baseline and 8-week follow-up

• Change in health-related quality of life through The Saint George's Respiratory Questionnaire (SGRQ)

  Baseline and 8-week follow-up

• Changes in Body Mass Index (BMI)

  Baseline and 8-week follow-up

• Changes in heart rate

  Baseline and 8-week follow-up

• Changes in blood pressure

  Baseline and 8-week follow-up

Study Arms (2)

Supervised isoinertial training

EXPERIMENTAL

Participants will perform a supervised isoinertial training program during 8 weeks of follow-up

Device: Isoinertial training

Traditional rehabilitation

ACTIVE COMPARATOR

Participants involved in the usual pulmonary rehabilitation program * The usual recommendations for physical activity and clinical follow-up will be maintained * No isoinertial training

Other: Traditional rehabilitation (control group)

Interventions

Isoinertial training DEVICE

Supervised isoinertial training: * Participants will perform a supervised isoinertial training program during 8 weeks of follow-up * The intervention will have a frequency of 2 to 3 weekly sessions * The program will include exercises aimed at strengthening the upper and lower limbs using a isoinertial device * The training load will be progressive to each participant and adjusted according to the individual response. * The program will be carried out in combination with usual pulmonary rehabilitation care.

Supervised isoinertial training

Traditional rehabilitation (control group) OTHER

Traditional treatment (control group) * Participants involved in the usual pulmonary rehabilitation program during 8 weeks with a frequency of 2-3 sessions per week. * This program includes low- to moderate-intensity aerobic exercise, joint mobility activities and general strengthening exercises using conventional resources according to the clinic's rehabilitation protocol. * No isoinertial training

Traditional rehabilitation

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• People between 50 - 80 years of age diagnosed with moderate or severe COPD
• No acute exacerbations in the last 4 weeks
• Sufficient functional capacity to exercise
• Signed informed consent

You may not qualify if:

• Presence of neurological, musculoskeletal, or cardiovascular diseases that significantly limit exercise performance or compromise participant safety; including uncontrolled hypertension, recent myocardial infarction, unstable angina, severe osteoarthritis, stroke sequelae, or Parkinson's disease.
• Contraindications to exercise participation according to medical evaluation.
• Recent surgeries in the past 3 months
• Simultaneous participation in other exercise programs
• Cognitive disorders

Sponsors & Collaborators

• Universidad Manuela Beltrán: lead

Study Sites (2)

Universidad Manuela Beltrán

Bogotá, Bogotá, DC, 110231, Colombia

Location

Pulsar Unidad de Neumologia y Rehabilitación Pulmonar

Ibague, Ibagué, 730006, Colombia

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Motor Activity; Lung Diseases

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Central Study Contacts

David Murcia-Lesmes, PhD

CONTACT

+571 5460600; david.murcia@docentes.umb.edu.co

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 5, 2026
• First Posted: May 22, 2026
• Study Start: May 7, 2026
• Primary Completion (Estimated): July 25, 2026
• Study Completion (Estimated): July 27, 2026
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CO (2)