Comparison of QLB and TFP Block for Postoperative Analgesia in Laparoscopic Inguinal Hernia

NCT07604259 | Not Yet Recruiting

• 1 other identifier: İnguinal QLB vs TFP
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial aims to compare the effects of ultrasound-guided lateral Quadratus Lumborum Block (QLB) and Transversalis Fascia Plane (TFP) block on postoperative analgesia in patients undergoing laparoscopic inguinal hernia repair. Ninety patients will be randomly assigned to one of three groups: Group QLB, Group TFP, or Group Control. The primary objective is to compare postoperative pain scores (NRS) at various time points within the first 24 hours. Secondary objectives include evaluating the need for rescue analgesia, total tramadol consumption, and the incidence of opioid-related side effects.

Conditions

İnguinal Hernia; Post Operative Pain

Keywords

Laparoscopic inguinal hernia, Quadratus Lumborum Block, Transversalis Fascia Plane Block, Postoperative analgesia, Regional anesthesia.

Outcome Measures

Primary Outcomes (1)

• Numeric Rating Scale (NRS) Pain Score

  Postoperative pain intensity assessed using the Numeric Rating Scale (NRS). The scale ranges from 0 to 10, where 0 indicates "no pain" and 10 indicates "worst imaginable pain". Higher scores represent worse pain outcomes.

  At 0, 3, 6, 12, 18, and 24 hours postoperatively.

Secondary Outcomes (4)

• Total Tramadol Consumption

  During the first 24 hours postoperatively.

• Need for Rescue Analgesia

  During the first 24 hours postoperatively

• Incidence of Opioid-Related Side Effects

  During the first 24 hours postoperatively.

• Incidence of Block-Related Complications

  During the first 24 hours postoperatively.

Study Arms (3)

Group QLB

EXPERIMENTAL

Patients will receive bilateral lateral Quadratus Lumborum Block (QLB) and port site infiltration at the end of the surgery.

Procedure: Lateral Quadratus Lumborum Block

Group TFP

EXPERIMENTAL

Patients will receive bilateral Transversalis Fascia Plane (TFP) block and port site infiltration at the end of the surgery.

Procedure: Transversalis Fascia Plane Block

Group Control

ACTIVE COMPARATOR

Patients will receive only port site infiltration at the end of the surgery.

Procedure: Port Site Infiltration

Interventions

Lateral Quadratus Lumborum Block PROCEDURE

Bilateral ultrasound-guided lateral QLB with 20 mL of 0.25% bupivacaine per side (total 40 mL). Plus, 10 mL of 0.25% bupivacaine infiltration at trocar insertion sites.

Group QLB

Transversalis Fascia Plane Block PROCEDURE

Bilateral ultrasound-guided TFP block with 20 mL of 0.25% bupivacaine per side (total 40 mL). Plus, 10 mL of 0.25% bupivacaine infiltration at trocar insertion sites.

Group TFP

Port Site Infiltration PROCEDURE

Local infiltration of 20 mL of 0.25% bupivacaine at the trocar insertion sites.

Group Control

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Scheduled for elective laparoscopic inguinal hernia repair.
• American Society of Anesthesiologists (ASA) physical status I, II, or III.
• Age between 18 and 65 years.
• Provided written informed consent.

You may not qualify if:

• History of allergy to local anesthetics.
• Presence of coagulopathy.
• Signs of infection at the intended block application site.
• Body Mass Index (BMI) ≥ 35 kg/m².
• History of chronic opioid use.
• Presence of neurological disease.
• Refusal to participate in the study.

Sponsors & Collaborators

• Medipol University: lead

Study Sites (1)

Istanbul Medipol University

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hernia, Inguinal; Pain, Postoperative

Condition Hierarchy (Ancestors)

Hernia, Abdominal; Hernia; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Postoperative Complications; Pathologic Processes; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assist. prof.

Study Record Dates

• First Submitted: May 18, 2026
• First Posted: May 22, 2026
• Study Start (Estimated): June 10, 2026
• Primary Completion (Estimated): April 10, 2027
• Study Completion (Estimated): May 10, 2027
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)