Mindfulness With Dual-Task Training in Post-Stroke Mild Cognitive Impairment

NCT07603102 | Recruiting

• 1 other identifier: NJKF202605002
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate whether a combined intervention of mindfulness and dual-task training can improve cognitive function and physical performance in individuals with mild cognitive impairment after stroke.

Conditions

Stroke; Mild Cognitive Impairment (MCI)

Outcome Measures

Primary Outcomes (1)

• Montreal Cognitive Assessment (MoCA)

  The Montreal Cognitive Assessment (MoCA) is a widely used neuropsychological tool for detecting mild cognitive impairment (MCI). It assesses multiple cognitive domains, including attention, executive function, memory, language, visuospatial ability, abstraction, calculation, and orientation. The total score is 30 points, with higher scores indicating better cognitive function.

  From enrollment to the end of treatment at 4 weeks

Study Arms (3)

MDT group

EXPERIMENTAL

Mindfulness + Dual-Task Training

Other: mindfulness; Device: Dual-Task Training

DT group

EXPERIMENTAL

Dual-Task Training + Health Education

Device: Dual-Task Training; Other: Health education

AT group

EXPERIMENTAL

Aerobic Training + Health Education

Device: Aerobic Training; Other: Health education

Interventions

mindfulness OTHER

Guided by a professional mindfulness instructor, participants engage in mindfulness meditation to enhance attention, emotional regulation, and cognitive readiness. The training includes breath awareness, body scan, and present-moment awareness, delivered through guided meditation.Other Name:

MDT group

Dual-Task Training DEVICE

Dual-task training is a rehabilitation approach that targets cognitive-motor integration by requiring participants to perform a motor task and a cognitive task simultaneously. Examples include walking while performing mental calculations, memory tasks, or reaction-based exercises. The training is progressively adjusted by increasing task difficulty and cognitive load to improve attention allocation, executive function, and dual-task performance in daily activities.

DT group; MDT group

Aerobic Training DEVICE

Dual-task training is a rehabilitation approach that targets cognitive-motor integration by requiring participants to perform a motor task and a cognitive task simultaneously. Examples include walking while performing mental calculations, memory tasks, or reaction-based exercises. The training is progressively adjusted by increasing task difficulty and cognitive load to improve attention allocation, executive function, and dual-task performance in daily activities.

AT group

Health education OTHER

Health education is a non-exercise control intervention designed to provide participants with knowledge related to post-stroke health management. Topics include stroke recovery, healthy lifestyle behaviors, nutrition, medication adherence, daily activity management, and psychological well-being. The intervention is delivered through structured educational sessions or instructional materials and does not include active physical or cognitive training components.

AT group; DT group

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI).
• Time since stroke onset ≥3 months and medically stable.
• Presence of mild cognitive impairment after stroke, defined by a Montreal - - Montreal Cognitive Assessment (MoCA) score \< 26.
• Mini-Mental State Examination (MMSE) score ≥ 24.
• Ability to walk independently with or without an assistive device for at least 10 meters.
• Stable medication regimen for at least 4 weeks prior to enrollment.
• Ability to understand study instructions and provide written informed consent.

You may not qualify if:

• Severe aphasia, visual impairment, hearing impairment, or communication disorders that interfere with assessment or training participation.
• Severe depression or other major psychiatric disorders.
• Other neurological diseases affecting cognition or movement (e.g., Parkinson's disease, multiple sclerosis, traumatic brain injury).
• Severe musculoskeletal, cardiovascular, or systemic diseases that contraindicate exercise participation.
• Participation in other structured cognitive or rehabilitation intervention programs within the past 3 months.
• Unstable medical condition or recurrent stroke during the study period.
• Inability to safely complete the training protocol as determined by the study investigators.

Sponsors & Collaborators

• Nanjing Mingzhou Rehabilitation Hospital: lead

Study Sites (1)

Nanjing Mingzhou Rehabilitation Hospital

Nanjing, China

RECRUITING

MeSH Terms

Conditions

Stroke; Cognitive Dysfunction

Interventions

Mindfulness

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Cognitive Behavioral Therapy; Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Central Study Contacts

Jingzhi Zhang

CONTACT

+86-16677137704; 170787717@qq.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: supervisor technician

Study Record Dates

• First Submitted: May 16, 2026
• First Posted: May 22, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)