NCT07602998

Brief Summary

The aim of this study was to determine the effect of the "love glove" intervention, combined with the voices of family members and nurses, on vital signs in unconscious patients in the intensive care unit. The following items will be used to collect research data: Patient Information Form (Appendix I), Data Recording Form (Appendix II), MP3 player, external headphones and voice recorder, latex gloves, and thermometer. Data Collection Tools: Patient Identification Form : A form containing patients' sociodemographic characteristics and their Glasgow Coma Scale score prior to the start of the study Data Recording Form: A form used to record patients' level of consciousness and hemodynamic parameters before and after the auditory stimulation procedure. Methods This study is a randomized controlled trial designed to determine the effect of applying a family member's voice, a nurse's voice, and the "love glove" on vital signs in unconscious patients admitted to the intensive care unit. Following approval from the ethics committee, the study is planned to be conducted with comatose patients admitted to the hospital's intensive care unit.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
22mo left

Started Jun 2026

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 23, 2026

Completed
2 months until next milestone

First Posted

Study publicly available on registry

May 22, 2026

Completed
10 days until next milestone

Study Start

First participant enrolled

June 1, 2026

Expected
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2026

1.8 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2028

Last Updated

May 22, 2026

Status Verified

May 1, 2026

Enrollment Period

Same day

First QC Date

March 23, 2026

Last Update Submit

May 16, 2026

Conditions

Keywords

Auditory StimulationLove GloveVital SignsTactile Stimulation

Outcome Measures

Primary Outcomes (3)

  • blood pressure

    Blood pressure were recorded on the Form before and after the blood sampling procedure.

    Twice a day for 7 days

  • pulse

    Pulse were recorded on the Form before and after the blood sampling procedure.

    Twice a day for 7 days

  • oxygen saturation

    oxygen saturation were recorded on the Form before and after the blood sampling procedure.

    Twice a day for 7 days

Study Arms (5)

Control

NO INTERVENTION

No intervention

family member's voice

EXPERIMENTAL

A pre-recorded message will be played and recorded for the patient's family members, featuring a prepared script that includes the patient's name, the family member's name, and their relationship to the patient, as well as information on the patient's location and phrases conveying hope and love.

Behavioral: Voice of a patient's relative

nurse's voice

EXPERIMENTAL

The audio recording made by the researcher will also be played for the other intervention group, to whom the nurse's voice will be played

Behavioral: Voice of nurse

Love glove

EXPERIMENTAL

The group receiving the "love glove" treatment will be given a treatment involving latex gloves filled with warm water and air

Behavioral: Love glove

family member's voice+glove of love

EXPERIMENTAL

The patient's family members voice and the "glove of love" will be used together

Behavioral: voice and love glove

Interventions

The audio recording of the patient's family member will be made in a quiet and calm room. Care will be taken to select family members who have a strong emotional bond with the patient for the recording. When determining which family member will be recorded, the patient's first-degree relatives will be consulted, and the family's collective decision will be taken into account; in addition to the family member being recorded, consent will be obtained from another family member who volunteers to serve as a witness for this person via a consent form. A preliminary interview will be conducted with the family member selected for the audio recording in a suitable room, and they will be asked to recite the standard script. Family members will be given as much time as they need to prepare for the audio recording.

family member's voice
Voice of nurseBEHAVIORAL

The audio recording containing the standard script to be read by the researcher will also be made in a quiet, calm room

nurse's voice
Love gloveBEHAVIORAL

Latex medical gloves will be filled with warm water (37°C) and air to prevent pressure ulcers and provide a sensation of human touch. The gloves will be connected to each other and placed on both of the patient's hands, and the treatment will be applied for 15 minutes.

Love glove

where the patient's voice and the "glove of love" are used together

family member's voice+glove of love

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients in a coma who have been hospitalized in the intensive care unit for at least 48 hours, have a Glasgow Coma Scale score of 8 or lower,
  • have no hearing problems,
  • are hemodynamically stable,
  • are either on mechanical ventilation or breathing spontaneously, have no history of head trauma,
  • have received informed consent from their legal representative

You may not qualify if:

  • Patients with open wounds,
  • those diagnosed with brain death,
  • those whose sedative or analgesic doses were adjusted during the study,
  • those with severe hemodynamic instability,
  • patients with latex allergies

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kivan Çevik Kaya

Manisa, MANİSAYunusemre, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Unconsciousness

Interventions

Voice

Condition Hierarchy (Ancestors)

Consciousness DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Respiratory Physiological PhenomenaCirculatory and Respiratory Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
CARE PROVIDER, OUTCOMES ASSESSOR
Masking Details
Although blinding of the investigators could not be achieved due to the nature of the interventions, the person assessing vital signs and the person conducting the statistical analysis will be blinded to the groups.
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Model Details: Patients will be assigned to 5 groups using a computer-assisted block randomization method. The study will be divided into 5 groups: the group receiving the patient's voice, the group receiving the nurse's voice, the group receiving the love glove, the combined group receiving both the patient's voice and the love glove, and the control group.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 23, 2026

First Posted

May 22, 2026

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

June 1, 2026

Study Completion (Estimated)

April 1, 2028

Last Updated

May 22, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Locations