Evaluation of Liquorice Nanogel Versus Diode Laser as an Adjunctive Treatment for Patients With Periodontitis Stage Ⅲ.

NCT07602738 | Completed Phase 3 DMC

• 1 other identifier: P-ME-24-10
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

Evaluation of the effect of liquorice nanogel versus diode laser on periodontitis stage Ⅲ clinically and microbiologically by molecular analysis of porphyromonas gingivalis using real time PCR.

Conditions

Diode Laser Therapy; Periodontal Disease; Liquorice Nanogel

Keywords

Liquorice Nanogel; Diode Laser; Real time pcr; P.gingivalis; 16s gene

Outcome Measures

Primary Outcomes (1)

• Quantitative analysis using real time pcr

  3 months

Study Arms (3)

control group

EXPERIMENTAL

no drug was added to control group

Drug: Liquorice Nanogel; Drug: diode laser

Liquorice Nanogel

EXPERIMENTAL

10% Liquorice was prepared in nanogel concentrate

Drug: Liquorice Nanogel; Drug: diode laser

Diode laser

EXPERIMENTAL

Epic X 0.9watt device was used

Drug: Liquorice Nanogel; Drug: diode laser

Interventions

Liquorice Nanogel DRUG

Real Time pcr was chosen to detect 16s gene concentration for porphyromonas gingivalis bacteria that is specific for Periodontitis Stage 3.

Diode laser; Liquorice Nanogel; control group

diode laser DRUG

Real time Pcr was used to detect gene concentration 16s specific for porphyromonas gingivalis

Diode laser; Liquorice Nanogel; control group

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patient had Periodontitis stage III with pocket depth ≥ 6mm; indicated for periodontal surgery or CAL ≥ 5mm.
• Patient agreed to the surgical procedure and clinical trial.
• Age ranged between 18-50 years old.

You may not qualify if:

• : No previous drug was taken affecting bone metabolism. 2- Smoking. 3- Pregnant women and women with menopause. 4- Patients with psychological problems . 5- Patients with abnormal habits. 6- Patients with medical conditions as Diabetes or Hypertension.

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Alazhar University for Girls

Cairo, Cairo Governorate, 00202, Egypt

Location

MeSH Terms

Conditions

Periodontal Diseases

Interventions

Lasers, Semiconductor

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Lasers; Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master Candidate of Oral and Dental Medicine and Periodontology Al Azhar University for girls

Model Details: Patient had Periodontitis stage III with pocket depth ≥ 6mm; indicated for periodontal surgery or CAL ≥ 5mm , Patient agreed to the surgical procedure and clinical trial, Age ranged between 18-50 years old. No previous drug was taken affecting bone metabolism , No Smokers Pregnant women and women with menopause were excluded. Patients with psychological problems were excluded. Patients with abnormal habits were excluded . Patients with medical conditions as Diabetes or Hypertension were excluded.

Study Record Dates

• First Submitted: May 12, 2026
• First Posted: May 22, 2026
• Study Start: July 1, 2024
• Primary Completion: September 28, 2025
• Study Completion: April 1, 2026
• Last Updated: May 22, 2026

Record last verified: 2026-05

Locations

EG (1)