The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury

NCT07602465 | Not Yet Recruiting DMC

• 1 other identifier: 2025ZDSYLL420
• Study Type: observational
• Target: 5,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients.

Conditions

Acute Kidney Injury (AKI)

Keywords

Acute kidney injury; Blood pressure variability; Anesthesia induction period; Non-cardiac surgery

Outcome Measures

Primary Outcomes (1)

• AKI

  AKI diagnosed according to KDIGO criteria within 7 days after surgery was the primary outcome event.

  Within 7 days after surgery.

Study Arms (4)

HH

High induction blood pressure variability + High surgery blood pressure variability

HL

High induction blood pressure variability + Low surgery blood pressure variability

LH

Low induction blood pressure variability + High surgery blood pressure variability

LL

Low induction blood pressure variability + Low surgery blood pressure variability

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Southeast University Zhongda Hospital (2013-2024), Nanjing First Hospital (2016-2024), and the First Affiliated Hospital of Anhui Medical University (2013-2023)

You may qualify if:

• Undergoing non-cardiac surgery；Adult；

You may not qualify if:

• Undergoing urological surgeries that partially directly affect kidney function (including relief of urinary tract obstruction, nephrectomy, or kidney transplantation);Surgery duration less than 120 minutes;Weight \< 30 kg or BMI \> 35;Patients who underwent reoperation within 7 days after surgery;Surgeries not performed under general anesthesia;ASA \> IV;No serum creatinine measurement available within 6 months before surgery (baseline value) or within 7 days after surgery;Preexisting renal dysfunction or a diagnosis of chronic kidney disease before surgery (creatinine \> 443 μmol/L);No invasive blood pressure monitoring during the anesthesia induction period, or missing more than 25% of intraoperative invasive blood pressure data collection.

Sponsors & Collaborators

• Zhongda Hospital: lead
• Nanjing First Hospital, Nanjing Medical University: collaborator
• The First Affiliated Hospital of Anhui Medical University: collaborator

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

Lingjue Chen

CONTACT

+86 18851656227; 760026195@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: attending doctor

Study Record Dates

• First Submitted: May 15, 2026
• First Posted: May 22, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share