NCT07601477

Brief Summary

We are trying to find out if personalized dosing of antidepressant medications using information gathered at the Personalized Medicine Clinic can improve patients' mental health. The main question it aims to answer is if the Personalized Medicine Clinic can improve depressive symptoms based on the CES-D survey score.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
23mo left

Started Jul 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 15, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

May 22, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

July 1, 2026

Expected
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2028

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2028

Last Updated

May 22, 2026

Status Verified

May 1, 2026

Enrollment Period

1.9 years

First QC Date

May 15, 2026

Last Update Submit

May 15, 2026

Conditions

Mental HealthDepressive DisorderPharmacogenetic TestingAntidepressant

Outcome Measures

Primary Outcomes (1)

  • CES-D Survey Score

    CES-D survey score is a 20-item self-reported questionnaire that was designed to assess depressive symptoms. The score is from 0-60 with higher numbers indicating greater depressive symptoms.

    From enrollment to 6 months

Study Arms (1)

Personalized Medicine Cohort

Patients referred to the Personalized Medicine Clinic for guidance on antidepressant therapy.

Other: Personalized Medicine Clinic

Interventions

Personalized Medicine ClinicOTHER

Personalized Medicine Clinic services with specific focus on pharmacogenetic recommendations and patient education.

Personalized Medicine Cohort

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult patients referred to the Personalized Medicine clinic for genotype-guided drug dosing and selection related to mental health pharmacotherapy as part of clinical care.

You may qualify if:

  • Depressive symptoms

You may not qualify if:

  • Patients who do not speak English, patients with severe mental illness including hospitalized patients or patients with suicidal ideation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Psychological Well-BeingDepressive Disorder

Condition Hierarchy (Ancestors)

Personal SatisfactionBehaviorMood DisordersMental Disorders

Central Study Contacts

Richard B Kim, MD

CONTACT

519-685-8500richard.kim@lhsc.on.ca

Denise Keller, PharmD

CONTACT

519-685-8500denise.keller@lhsc.on.ca

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Clinical Pharmacologist

Study Record Dates

First Submitted

May 15, 2026

First Posted

May 22, 2026

Study Start (Estimated)

July 1, 2026

Primary Completion (Estimated)

June 1, 2028

Study Completion (Estimated)

June 1, 2028

Last Updated

May 22, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share