Frequency of Platelets Transfusion & Post-Operative Bleeding Risk in Patients on Clopidogrel Undergoing CABG

NCT07600060 | Completed

• 1 other identifier: 2023-9576-27366
• Study Type: observational
• Target: 227
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this retrospective cohort study Is to Primarily be platelet transfusion frequency and postoperative bleeding risk, analysis using descriptive and inferential statistics in all eligible patients admitted to the cardiac intensive care unit (CICU) for open-heart surgery were included of both gender, age group of 30-80 years. The main questions it aims to answer are:

• How was the frequency of platelet transfusion during the index admission evaluated?
• How was post-operative bleeding risk measured?
• What does 24-hour chest drain output indicate in this context?
• How was packed cell volume (PCV) transfusion used as an outcome measure?

Conditions

Patients on Clopidogrel; Platelets Transfusion

Keywords

Post-Operative Bleeding Risk in Patients

Outcome Measures

Primary Outcomes (1)

• Frequency of platelet transfusion

  The frequency of platelet transfusion during the hospital stay.

  From the day 1 of admission till discharge or 30 days of admission

Other Outcomes (1)

• Time to re-intubation

  30-60 seconds from laryngoscope insertion in the oral cavity tilldetection of end tidal carbon dioxide trace.

Eligibility Criteria

• Age: 30 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All eligible patients admitted to the cardiac intensive care unit (CICU) for open-heart surgery were included.

You may qualify if:

• CICU patients who underwent cardiac surgery
• Adults aged 30-80 years undergoing cardiac surgery with cardiopulmonary bypass
• Patients who received dual antiplatelet therapy, last dose within 5 days before surgery

You may not qualify if:

• BMI \> 40 kg/m²
• Repeat open-heart surgery (reoperation)
• Transferred open-chest procedures
• Active liver disease
• Chronic lung disease
• Dialysis dependence
• Intra-aortic balloon pump (IABP) in place pre- or post-operatively
• Major neurological deficit within the past 6 months
• Incomplete clinical records

Sponsors & Collaborators

• Aga Khan University: lead

Study Sites (1)

Aga khan University

Karachi, Sindh, 7480 0, Pakistan

Location

Study Officials

• Khalid Siddiqui, MBBS-FCPS

  Aga Khan University

  PRINCIPAL INVESTIGATOR

• Khalid Siddiqui

  Aga Khan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 25, 2026
• First Posted: May 20, 2026
• Study Start: July 1, 2022
• Primary Completion: May 31, 2023
• Study Completion: June 30, 2023
• Last Updated: May 20, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)