NCT07599735

Brief Summary

The feasibility and acceptability of a collaborative deprescribing intervention to reduce anticholinergic burden among hospitalised older patients

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
21

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started May 2025

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 22, 2025

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2026

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

May 14, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

May 20, 2026

Completed
Last Updated

May 20, 2026

Status Verified

May 1, 2026

Enrollment Period

9 months

First QC Date

May 14, 2026

Last Update Submit

May 14, 2026

Conditions

Eligible Patients Are Aged 65 Years or More Admitted to One of the Five Medicines for Older People Wards, Who Have ACB Score of 3 or More

Keywords

anticholinergic burdenolder peoplepolypharmacyfrailty

Outcome Measures

Primary Outcomes (7)

  • number of medications

    number of medications

    Baseline and 3 months

  • anticholinergic burden scores

    anticholinergic burden scores

    baseline and 3 months

  • Activities of Daily Living

    Activities of Daily Living

    Baseline and 3 months

  • frailty status

    frailty status

    Baseline and 3 months

  • cognition

    cognition

    Baseline and 3 months

  • Health related quality of life (SF36)

    Heath related quality of life (SF36)

    Baseline and 3 months

  • delirium

    delirium

    Baseline and 3 months

Secondary Outcomes (2)

  • Healthcare resouce use

    Baseline and 3 months

  • adverse events

    Baseline and 3 months

Interventions

Patients will receive a collaborative deprescribing interventionOTHER

Patients will receive a collaborative deprescribing intervention including: 1) pharmacist-led identification of patients using TRISCRIBE digital tool and highlighting anticholinergics medications on their clinical notes for targeted deprescribing, 2) doctor-led medication review to stop, reduce dose or switch to safer alternatives based on individual patient needs, and 3) highlighting and communicating medication changes to GP on discharge summaries.

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients aged 65 years or more admitted to one of the five Medicine for Older People wards, who have ACB score of 3 or more

You may qualify if:

  • Eligible patients aged 65 years or more admitted to one of the five Medicine for Older People wards, who have ACB score of 3 or more

You may not qualify if:

  • Those who are expected to have a limited life expectancy, receiving palliative care will be excluded.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Southampton

Southampton, United Kingdom

Location

Related Links

MeSH Terms

Conditions

Frailty

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Kinda Ibrahim, PhD

    University of Southampton

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

May 14, 2026

First Posted

May 20, 2026

Study Start

May 22, 2025

Primary Completion

February 1, 2026

Study Completion

February 1, 2026

Last Updated

May 20, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

The individual participant data (IPD) that support the findings of this study are not publicly available due to privacy and confidentiality restrictions. The dataset contains small sample size and potentially identifiable information, and sharing the raw data could compromise participant confidentiality. Aggregated data supporting the findings will be included within the published article.

Locations

GB(1)