Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial
1 other identifier
interventional
100
1 country
1
Brief Summary
The relationship between different root canal irrigation techniques and pain after root canal treatment
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_4
Started Jan 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2025
CompletedFirst Submitted
Initial submission to the registry
May 1, 2025
CompletedFirst Posted
Study publicly available on registry
May 20, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 5, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 15, 2026
May 20, 2026
May 1, 2025
1.4 years
May 1, 2025
May 14, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Evaluation of the relationship between different root canal irrigation techniques and post-canal treatment pain using surveys.
3-5 month
Study Arms (4)
NaOCl/EDTA+CNI Group
EXPERIMENTALİrrigation
NaOCl/EDTA+PUA Group
EXPERIMENTALNaOCl/Dual Rinse HEDP+CNI Group
EXPERIMENTALNaOCl/Dual Rinse HEDP+PUA Group
EXPERIMENTALInterventions
Root canal irrigation and postoperative pain
Eligibility Criteria
You may qualify if:
- o Patients aged 18-60 years who are classified as medically healthy (ASA I or II),
- Mature, single-rooted and canal teeth that had root canal treatment at least four years ago,
- Teeth with previous root canal obturation 2-4 mm short of the apex,
- Teeth that do not need periodontal and prosthetic treatment and whose periapical index score (PAI) is between 2 and 4 ,
- Teeth with single root and canal diagnosed with asymptomatic apical periodontitis,
- Teeth suitable for rubber dam isolation.
You may not qualify if:
- o Patients who had taken analgesics, antibiotics, or corticosteroids within two weeks before root canal retreatment,
- Teeth exhibiting periodontal attachment loss,
- Presence of vertical root fractures, external root resorption, or perforations,
- Teeth with retained broken instruments,
- Non-restorable teeth,
- Patients in the pregnancy and breastfeeding period.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Erciyes University
Kayseri, Turkey (Türkiye)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr.
Study Record Dates
First Submitted
May 1, 2025
First Posted
May 20, 2026
Study Start
January 1, 2025
Primary Completion (Estimated)
June 5, 2026
Study Completion (Estimated)
July 15, 2026
Last Updated
May 20, 2026
Record last verified: 2025-05
Data Sharing
- IPD Sharing
- Will not share