Photobiomodulation Therapy (PBMT) for Accelerating Maxillary Canine Movement Using Two Wavelengths (650 nm and 976 nm): A Split-Mouth Randomized Controlled Clinical Trial

NCT07597304 | Completed DMC

• 2 other identifiers: PBMT-CANINE-2026KU-IRB-2026-1-2
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

movement using low-level laser therapy with different wavelengths. Participants will receive laser application during orthodontic treatment, and the rate of canine movement will be measured and compared between the study groups. The results may help determine whether low-level laser therapy can accelerate orthodontic tooth movement safely and effectively.

Conditions

Orthodontic Treatment Acceleration; Photobiomodulation Therapy

Keywords

Photobiomodulation Therapy Low-Level Laser Therapy Orthodontics Canine Retraction Orthodontic Tooth Movement

Outcome Measures

Primary Outcomes (1)

• Rate of Maxillary Canine Movement

  Measurement of the amount of maxillary canine movement during orthodontic retraction following application of photobiomodulation therapy using 650 nm and 976 nm wavelengths.

  6 months

Secondary Outcomes (2)

• Correlation Between Age and Rate of Canine Retraction

  6 months

• Difference in Rate of Canine Retraction Between Sexes

  6 months

Study Arms (2)

650 nm PBMT

EXPERIMENTAL

Participants receive photobiomodulation therapy using a 650 nm laser during maxillary canine retraction.

Device: 650 nm Photobiomodulation Therapy

976 nm PBMT

EXPERIMENTAL

Participants receive photobiomodulation therapy using a 976 nm laser during maxillary canine retraction.

Device: 976 nm Photobiomodulation Therapy

Interventions

650 nm Photobiomodulation Therapy DEVICE

Application of 650 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement.

650 nm PBMT

976 nm Photobiomodulation Therapy DEVICE

Application of 976 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement.

976 nm PBMT

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• good oral hygiene and the absence of any medications affecting bone metabolism.

You may not qualify if:

• systemic diseases, periodontal pathology, a history of previous orthodontic treatment, or the use of antibiotics or anti-inflammatory drugs during the study.\[

Sponsors & Collaborators

• Kufa University: lead

Study Sites (1)

Orthodontic Clinic, College of Dentistry, University of Kufa

Najaf, Najaf Governorate, 54001, Iraq

Location

Related Publications (4)

• Alhumadi A. Gender-related response to different wavelength low-level laser therapy in orthodontic mandibular canine movement: a split-mouth study. Endodontics Today. 2026;24:58-66. doi:10.36377/ET-0159.

  BACKGROUND

• Al-Kufi HM, Alhumadi A, Huthiafa SM. A comparative evaluation of postoperative re-pigmentation following gingival depigmentation using a 940-nm diode laser and abrasion method: a split-mouth study. Lasers in Dental Science. 2024;8(1):3. doi:10.1007/s41547-023-00208-y.

  BACKGROUND

• Zheng J, Yang K. Clinical research: low-level laser therapy in accelerating orthodontic tooth movement. BMC Oral Health. 2021 Jun 28;21(1):324. doi: 10.1186/s12903-021-01684-z.

  PMID: 34182967 BACKGROUND

• Wazwaz F, Seehra J, Carpenter GH, Papageorgiou SN, Cobourne MT. Duration of canine retraction with fixed appliances: A systematic review and meta-analysis. Am J Orthod Dentofacial Orthop. 2023 Feb;163(2):154-172. doi: 10.1016/j.ajodo.2022.08.009. Epub 2022 Dec 1.

  PMID: 36464569 BACKGROUND

MeSH Terms

Interventions

Low-Level Light Therapy

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: This is an open-label study in which both the investigator and participants are aware of the laser wavelength applied during treatment.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer

Model Details: This study uses a split-mouth randomized clinical trial design in which each participant serves as their own control. Maxillary canine retraction will be performed bilaterally following premolar extraction. Different photobiomodulation therapy wavelengths (650 nm and 976 nm) will be applied according to the randomization protocol during orthodontic canine movement.

Study Record Dates

• First Submitted: May 12, 2026
• First Posted: May 19, 2026
• Study Start: May 5, 2025
• Primary Completion: March 6, 2026
• Study Completion: March 20, 2026
• Last Updated: May 19, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

IR (1)