Hematological Indices and Sympathetic Block Response in Neuropathic Pain

NCT07596823 | Not Yet Recruiting

• 1 other identifier: 13579
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the relationship between hematological inflammatory indices and clinical treatment response in patients with neuropathic pain undergoing sympathetic nerve block procedures as part of routine clinical care. Hematological parameters including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), aggregate index of systemic inflammation (AISI), and red cell distribution width (RDW) will be evaluated before and after treatment. The association between changes in these indices and pain outcomes will be analyzed.

Conditions

Neuropathic Pain; Neuropathic Pain Diagnostic Questionnaire (DN4) ≥ 4

Keywords

Neuropathic Pain; Sympathetic Nerve; Inflammation

Outcome Measures

Primary Outcomes (1)

• Treatment Response at Month 3

  Treatment response will be defined as achieving at least 50% reduction in Numeric Rating Scale (NRS) pain score compared with baseline. NRS 0 means = no pain NRS 10 means= worst pain imaginable

  3 th month

Secondary Outcomes (3)

• NRS (Numeric Rating Scale Pain Score)

  Baseline and 3rd month

• Change in Hematological Inflammatory Indices

  Baseline and 3rd monnth

• GPE (Global Perceived Effect)

  3rd month

Study Arms (1)

Neuropathic Pain Cohort

Adult patients diagnosed with neuropathic pain undergoing sympathetic nerve block procedures as part of routine clinical care in the Algology Clinic of Ankara Bilkent City Hospital.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients diagnosed with neuropathic pain and undergoing sympathetic nerve block procedures in the Algology Clinic of Ankara Bilkent City Hospital.

You may qualify if:

• Age ≥18 years
• Diagnosis of neuropathic pain based on clinical evaluation
• DN4 and/or LANSS scores compatible with neuropathic pain
• Undergoing sympathetic nerve block as part of routine clinical treatment
• Availability of pre-treatment and follow-up hemogram parameters
• Ability to provide written informed consent

You may not qualify if:

• Age \<18 years
• Active infection or acute inflammatory disease
• Active malignancy
• History of hematological disease
• Immunosuppressive therapy or systemic corticosteroid use
• Major surgery or severe trauma within the last month
• Pregnancy or breastfeeding
• Autoimmune or rheumatologic inflammatory disease
• Missing follow-up data

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, Cankaya, 06680, Turkey (Türkiye)

Location

Related Publications (1)

• Babaoglu G, Sabuncu U, Dadali S, Costu A, Akcaboy EY. Discriminative role of inflammatory indices in clinical response to ganglion impar blockade: A retrospective cohort study. Medicine (Baltimore). 2026 Feb 6;105(6):e47638. doi: 10.1097/MD.0000000000047638.

  PMID: 41650048 RESULT

MeSH Terms

Conditions

Neuralgia; Inflammation

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Central Study Contacts

Ülkü Sabuncu, Assoc prof

CONTACT

905337085212; sabuncuulku@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc Prof

Study Record Dates

• First Submitted: May 13, 2026
• First Posted: May 19, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): January 31, 2027
• Last Updated: May 19, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)