The Effect of Detrusor Underactivity in Determining Outcomes After Transurethral Resection of the Prostate for Treatment of Benign Prostatic Hyperplasia

NCT07596537 | Not Yet Recruiting

• 1 other identifier: Detrusor Underactivity & TURP
• Study Type: interventional
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this clinical trial is to evaluate the effect of detrusor underactivity on the functional and symptomatic outcomes following transurethral resection of the prostate (TURP) in benign prostatic hyperplasia patients presenting with chronic urinary retention. The main questions it aims to answer are: Will they restore spontaneous voiding? They will be divided into 2 comparative groups (each group 45 patients) based on detrusor contractility.

• Group (A) consists of patients with normal detrusor (bladder contractility index more than 100).
• Group (B) consists of patients with underactive detrusor (bladder contractility index less than 100).

Conditions

Detrusor Underactivity; Transurethral Resection of the Prostate (TURP)

Outcome Measures

Primary Outcomes (1)

• Restore spontaneous voiding

  All the included patients in this study are urethral catheter-dependant pre-operatively and have very bad voiding parameters. we will assess how they will benefit after TURP by regaining spontaneous voiding without the need for urethral catheters any more.

  3 months

Secondary Outcomes (2)

• Flow rate improvement

  3 months

• Post voiding residual urine volume decrease

  3 months

Study Arms (2)

consists of patients with underactive detrusor (bladder contractility index less than 100).

ACTIVE COMPARATOR

• Group (B) - Underactive Detrusor

Procedure: transurethral resection of Prostate

consists of patients with normal detrusor (bladder contractility index more than 100).

ACTIVE COMPARATOR

• Group (A) - Normal detrusor

Procedure: transurethral resection of Prostate

Interventions

transurethral resection of Prostate PROCEDURE

Standard TURP

consists of patients with normal detrusor (bladder contractility index more than 100).; consists of patients with underactive detrusor (bladder contractility index less than 100).

Eligibility Criteria

• Age: 50 Years+
• Gender Eligibility Details: Male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age: more than 50-year-old
• Chronic urinary retention secondary to BPH
• Prostate size Above 30 and less than 100gm

You may not qualify if:

• Prostate size over 100 gm and less than 30 gm
• Prostatic carcinoma
• Urinary bladder carcinoma
• Acute urinary retention
• Urethral stricture.
• Previous bladder, urethral or prostate surgery.
• Acute urinary tract infection.
• Neurogenic bladder

Sponsors & Collaborators

• Ain Shams University: lead

MeSH Terms

Conditions

Urinary Bladder, Underactive

Interventions

Transurethral Resection of Prostate

Condition Hierarchy (Ancestors)

Urinary Bladder Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Lower Urinary Tract Symptoms; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Prostatectomy; Urologic Surgical Procedures, Male; Urologic Surgical Procedures; Urogenital Surgical Procedures; Surgical Procedures, Operative

Central Study Contacts

Samir Sherif Rizkallah, MBBCH

CONTACT

+201226846005; 150278@med.asu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 5, 2026
• First Posted: May 19, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: May 20, 2026

Record last verified: 2026-05