Investigating the (Cost-)Effectiveness of an Online Social Therapy Platform (ENYOY) for Young People Aged 16-25 on Mental Healthcare Waiting Lists

NCT07594756 | Not Yet Recruiting DMC

• 1 other identifier: NL-010792
• Study Type: interventional
• Target: 225
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study, run by Amsterdam UMC in the Netherlands, looks at whether an online mental health platform called ENYOY can help improve psychological distress in young people (16-25) who are waiting for mental health care. Young people in the Netherlands aged 16 to 25 can take part if they are experiencing mental health problems, and are currently on a waiting list for mental healthcare. The study lasts 12 months. During this time, participants fill in questionnaires four times (at the start, at 3-months, 6-months, and 12-months). After joining the study, participants are randomly placed into one of two groups:

• Intervention group: receives access to the ENYOY platform plus care-as-usual.
• Control group: receive care-as-usual. Young people in the intervention group can use the platform for the duration of the study period, with three months of guidence by a coach and/or peer with lived experience with mental health complaints. The platform includes activities based on proven psychological methods. These activities help with things like low mood, anxiety, sleep problems, and confidence. They also get support from a coach and/or a peer (someone who has experienced mental health problems themselves), and access to a safe online community where young people can talk, share experiences, and support each other. The community is moderated to keep it safe and supportive. Taking part may help young people feel psychological stress and improve their mental health. There are no known risks from taking part in this study. Participant recruitment will take place from May 2026 to December 2027. Final follow-up assessments are expected to be completed by December 2028. The study is funded by ZonMw. For questions, you can contact Sascha Struijs (s.y.struijs@vu.nl), or Fenna Hellegers (f.hellegers@amsterdamumc.nl)

Conditions

Psychological Distress

Keywords

Psychological distress; Young people; DMHI; ENYOY; MOST; Waiting list

Outcome Measures

Primary Outcomes (1)

• Psychological distress

  Psychological distress will be measured using the Clinical Outcomes in Routine Evaluation-10 measurement (Barkham et al., 2013). The minimum score is 0 and the maximum score is 40. Higher scores indicate higher levels of psychological distress.

  At 3-month follow-up

Secondary Outcomes (9)

• Psychological distress

  At 6-, and 12-month follow-up

• Functioning

  at 3-month, 6-month, and 12-month follow-up

• Quality of life

  at 3-month, 6-month, and 12-month follow-up

• Depression

  at 3-month, 6-month, and 12-month follow-up

• Anxiety

  at 3-month, 6-month, and 12-month follow-up

Other Outcomes (5)

• Reach

  at 3-month, 6-month, and 12-month follow-up

• Adoption

  at 3-month, 6-month, and 12-month follow-up

• Implementation

  at 3-month, 6-month, and 12-month follow-up

Study Arms (2)

Experimental condition

EXPERIMENTAL

Young people in this group receive access to the ENYOY platform, along with three months of guidance from a coach and/or a peer with lived experience of mental health difficulties, in addition to Care-As-Usual.

Behavioral: ENYOY

Control condition

OTHER

Young people in the control condition receive Care As Asual.

Other: Care As Usual

Interventions

ENYOY BEHAVIORAL

ENYOY is an evidence-based digital mental health platform co-created with young people. It combines four main elements: interactive therapeutic content, guidence by coaches and/or peers with lived experience with mental health complaints, and a moderated online community. The therapeutic content is based on approaches like cognitive behavioral therapy and is tailored into "journeys" that match a young person's needs, such as improving mood, reducing anxiety, or building confidence. Users can explore activities and build a personal toolkit. The online community offers young people a safe social space where young people can connect, share experiences, and support each other. Engagement is encouraged through discussions, prompts, and optional anonymous participation. Safety is closely monitored through both human moderation and automated systems that detect risk.

Also known as: MOST

Experimental condition

Care As Usual OTHER

Young people in the control condition receive Care As Usual.

Control condition

Eligibility Criteria

• Age: 16 Years - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Age 16-25 years
• On a waiting list for mental healthcare
• Able and willing to consent
• A score of 10 or higher on the CORE-10 questionnaire
• Have personal and private access to a computer, smartphone or tablet.
• Ability and willingness to nominate an emergency contact person, such as a close family member

You may not qualify if:

• Insufficient command of the Dutch language
• Present with acute suicidal behavior or imminent risk of harm to self
• If their psychiatric symptoms are due to an organic cause
• Prior exposure to ENYOY or MOST

Sponsors & Collaborators

• Levvel: collaborator
• Psychiatric Clinic of Mondriaan Heerlen-Maastricht: collaborator
• Academisch Medisch Centrum - Amsterdam UMC Research BV: lead

Related Links

• Data from this study will be shared with the YOUTHreach consortium. This study registration descripes the aim and design of their study.

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr. Arne Popma

Study Record Dates

• First Submitted: May 6, 2026
• First Posted: May 19, 2026
• Study Start: May 18, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: May 19, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will share