Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder

NCT07594717 | Recruiting

• 2 other identifiers: 2328661-2K01DA062708
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This study examines the effects of e-cigarette (EC) flavors among adults with opioid use disorder (OUD) receiving buprenorphine treatment who currently use e-cigarettes. Participants will smell and rate 11 EC flavors based on appeal, sensory characteristics, and likelihood of future use. Researchers will examine how different flavor profiles influence the appeal and reinforcing effects of ECs in this population. The goal is to identify EC flavors that may enhance the acceptability of ECs as a potential harm-reduction strategy among adults with OUD receiving buprenorphine treatment.

Conditions

Nicotine Use Disoder; Opioid Use Disorder

Outcome Measures

Primary Outcomes (6)

• Perceived Sweetness

  Perceived sweetness of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not sweet at all" to "Extremely sweet," with higher scores indicating greater perceived sweetness.

  Baseline session

• Perceived Coolness/Freshness

  Perceived coolness/freshness of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not cool/fresh at all" to "Extremely cool/fresh," with higher scores indicating greater perceived coolness/freshness.

  Baseline session

• Perceived Flavor Strength

  Perceived flavor strength will be assessed using a one-item VAS ranging from "Very weak" to "Very strong," with higher scores indicating greater perceived flavor strength.

  Baseline session

• Perceived Harshness/Irritation

  Perceived harshness/irritation of each e-cigarette flavor will be assessed using a one-item VAS ranging from "Not harsh/irritating at all" to "Extremely harsh/irritating," with higher scores indicating greater perceived harshness/irritation.

  Baseline session

• Flavor Liking

  Flavor liking will be assessed using a one-item VAS ranging from "Not at all" to "Extremely," with higher scores indicating greater liking of the flavor.

  Baseline session

• Likelihood of Future Use

  Likelihood of future use will be assessed using a one-item VAS ranging from "Not at all" to "Definitely," with higher scores indicating greater likelihood of future use of the flavor.

  Baseline session

Interventions

Sweet-cooling DRUG

Sweet-cooling EC flavor

Sweet non-cooling EC flavor DRUG

Sweet non-cooling flavor

Tobacco flavor EC DRUG

Tobacco flavor EC

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

E-cigarette users with opioid use disorder receiving burpenorphine

You may qualify if:

• Adults aged 21 years or older.
• Current e-cigarette users who report e-cigarette use on ≥20 of the past 30 days.
• Former daily cigarette smokers who currently smoke on ≤19 days per month and no more than 5 cigarettes per day.
• Diagnosed with opioid use disorder (OUD).
• Currently receiving buprenorphine treatment for OUD.

Sponsors & Collaborators

• Prisma Health-Upstate: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

Prisma Health Recovery Clinic-Greenville

Greenville, South Carolina, 29605, United States

RECRUITING

MeSH Terms

Conditions

Opioid-Related Disorders

Condition Hierarchy (Ancestors)

Narcotic-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Central Study Contacts

Irene Pericot-Valverde, PhD

CONTACT

18549998005; iperico@clemson.edu

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 13, 2026
• First Posted: May 19, 2026
• Study Start: November 12, 2025
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: May 22, 2026

Record last verified: 2026-05

Locations

US (1)