Normative Swallowing Physiological Metrics of Pharyngeal High-Resolution Impedance Manometry in Chinese Adults

NCT07594561 | Not Yet Recruiting

• 1 other identifier: 202603162RINA
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

As Taiwan enters a super-aged society in 2025, the number of elderly patients and patients with multiple comorbidities continues to increase, and the risk of dysphagia rises with advancing age. Due to neuronal degeneration and muscle atrophy, older adults often experience delayed recovery of swallowing function after general anesthesia, and it may take up to seven days to regain their baseline swallowing ability. Therefore, postoperative monitoring of swallowing function and early rehabilitative intervention are crucial for reducing complication risks and facilitating early discharge. Currently, there is limited literature regarding normative data for pharyngeal swallowing assessment using high-resolution pharyngeal manometry with impedance as well as videofluoroscopic swallowing studies in the Chinese population. This project aims to recruit 80 healthy adults to establish normative reference values.

Conditions

Hypopharyngeal Peak Pressure

Keywords

normal value; high resolution impedance manometry

Outcome Measures

Primary Outcomes (1)

• hypopharyngeal mean peak pressure

  pharyngeal contraction

  15 min

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

normal patients withour dysphagia

You may qualify if:

• Adults aged 18 years or older without subjective swallowing difficulty.

You may not qualify if:

• (1) Major systemic diseases, including heart failure, liver cirrhosis, end-stage renal disease, scleroderma, or diabetes mellitus; (2) History of vasovagal syncope, acute inflammation, or nasal or esophageal stenosis/obstruction; (3) Presence of upper gastrointestinal symptoms within the past 3 months, including dysphagia, chest pain, heartburn, reflux, or globus sensation; (4) Current use of medications that may affect gastrointestinal motility; (5) Use of anticoagulant or antiplatelet agents within 1 week prior to enrollment; or (6) History of bleeding tendency.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Central Study Contacts

Chi-Jun Lai

CONTACT

0972652086; littlecherrytw@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 13, 2026
• First Posted: May 19, 2026
• Study Start: May 20, 2026
• Primary Completion (Estimated): December 31, 2031
• Study Completion (Estimated): December 31, 2032
• Last Updated: May 19, 2026

Record last verified: 2026-05