Effect of Korean Ginseng Extract on Fatigue

NCT07590713 | Completed

• 1 other identifier: IRB-2023-01l
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluated whether eight weeks of Korean ginseng extract supplementation could affect exercise performance, body composition, and selected blood-based physiological markers in healthy adults. A total of 60 healthy adults aged 20 to 50 years were recruited and randomly assigned to either a Korean ginseng extract group or a placebo group in a double-blind, placebo-controlled design. Participants consumed one 10 mL packet of Korean ginseng extract or placebo daily for eight weeks. Assessments were performed before and after the intervention. Outcome measures included exercise performance tests, body composition, endocrine markers, inflammatory markers, oxidative stress markers, immune cell indices, and blood cell counts. Forty-nine participants completed the post-intervention assessments. The study was approved by the University of Taipei Institutional Review Board under approval number IRB-2023-011.

Conditions

Obesity & Overweight; Metabolic Syndrome

Keywords

Korean ginseng extract; Ginseng supplementation; Fatigue; Body composition

Outcome Measures

Primary Outcomes (1)

• Change in Biceps Strength

  Change in biceps isokinetic strength from baseline to after eight weeks of supplementation, assessed using an isokinetic dynamometer.

  Baseline and 8 weeks

Secondary Outcomes (1)

• Change in VO2max

  Baseline and 8 weeks

Study Arms (2)

Korean Ginseng Extract Group

EXPERIMENTAL

Participants received one 10 mL packet of Korean ginseng extract daily for eight weeks.

Dietary Supplement: Korean Ginseng Extract

Placebo Group

PLACEBO COMPARATOR

Participants received one 10 mL packet of placebo daily for eight weeks. The placebo was designed to have a similar taste and appearance to the Korean ginseng extract supplement.

Other: Placebo

Interventions

Korean Ginseng Extract DIETARY_SUPPLEMENT

Korean ginseng extract supplement, provided as one 10 mL packet daily for eight weeks. The supplement contained ginseng extract, water, and fructooligosaccharides.

Korean Ginseng Extract Group

Placebo OTHER

Placebo supplement, provided as one 10 mL packet daily for eight weeks. The placebo was designed to have a similar taste and appearance to the Korean ginseng extract supplement and contained water, maltodextrin, fructooligosaccharides, and casein phosphopeptide.

Placebo Group

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults aged 20 to 50 years.
• Able and willing to participate in the study.
• Able to provide written informed consent.

You may not qualify if:

• Allergy to ginseng products.
• History of cardiovascular disease, asthma, diabetes, liver disease, kidney disease, arrhythmia, or other chronic diseases.
• Current use of medications for chronic diseases.
• Habitual use of ginseng or other traditional Chinese medicine-related supplements.
• Pregnancy or breastfeeding.
• Menopausal women.

Sponsors & Collaborators

• University of Taipei: lead

Study Sites (1)

Institute of Sports Sciences, University of Taipei

Taipei, Taipei City, 111, Taiwan

Location

MeSH Terms

Conditions

Obesity; Overweight; Metabolic Syndrome; Fatigue

Interventions

Asian ginseng

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Participants and investigators were masked to group assignment. The placebo was designed to have a similar taste and appearance to the Korean ginseng extract supplement.
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Participants were randomly assigned in a 1:1 ratio to receive either Korean ginseng extract or placebo once daily for eight weeks.

Study Record Dates

• First Submitted: May 10, 2026
• First Posted: May 15, 2026
• Study Start: June 27, 2023
• Primary Completion: April 9, 2024
• Study Completion: April 9, 2024
• Last Updated: May 19, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)