Home-Based Exercise Programs for Fall Prevention in Parkinson Disease

NCT07590700 | Recruiting

• 1 other identifier: 2025/02-44
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Falls are common in patients with Parkinson disease and may lead to reduced mobility, fear of falling, loss of independence, and injury. Exercise-based rehabilitation programs may help improve balance, gait, and physical performance in this population. This randomized controlled trial aims to compare the effectiveness of two home-based exercise programs in patients with Parkinson disease: the Otago Exercise Program and a structured home exercise program. Participants will be randomly assigned to one of two groups. Both groups will receive exercise education and will perform their assigned home exercise program for 6 weeks. Participants will be evaluated at baseline, at week 3, and at the end of week 6. The study will assess fall-related outcomes, freezing of gait, functional mobility, gait parameters, postural control, and physical performance. The results may help determine which home-based exercise approach is more effective for reducing fall risk and improving functional outcomes in patients with Parkinson disease.

Conditions

PARKINSON DISEASE (Disorder); Falls Prevention; Exercise

Keywords

parkinson disease; fall prevention; Otago; Home-based; Execise

Outcome Measures

Primary Outcomes (1)

• Falls Efficacy Scale

  Fall-related self-efficacy and fear of falling will be assessed using the Falls Efficacy Scale. The scale evaluates the participant's confidence in performing daily activities without falling. Scores range from 10 to 100, with lower scores indicating greater fear of falling and higher scores indicating lower fear of falling.

  Baseline, week 3, and week 6

Secondary Outcomes (6)

• Freezing of Gait Questionnaire (FOGQ)

  Baseline, week 3, and week 6

• Gait Speed

  Baseline, week 3, and week 6

• Timed Up and Go Test

  Baseline, week 3, and week 6

• Functional Reach Test

  Baseline, week 3, and week 6

• Sit-to-Stand Test

  Baseline, week 3, and week 6

Study Arms (2)

Otago Home Exercise Program

EXPERIMENTAL

Participants in this arm will receive the Otago Home Exercise Program. The program includes home-based strengthening, static balance, and dynamic balance exercises designed to improve lower extremity muscle strength, balance, functional mobility, and fall-related outcomes. Participants will perform the exercises 3 times per week for 6 weeks, with each session lasting approximately 40 minutes. The exercise program will be reviewed and progressed at week 3 according to the participant's functional status.

Behavioral: Otago Home Exercise Program

Structured Home Exercise Program

ACTIVE COMPARATOR

Participants in this arm will receive a structured home exercise program. The program includes spinal stabilization exercises and stretching and strengthening exercises targeting the ankle plantar flexor and dorsiflexor muscles, quadriceps, lumbar extensor muscles, pectoral muscles, and hamstring muscles. Participants will perform the exercises 3 times per week for 6 weeks, with each session lasting approximately 40 minutes. The exercise program will be reviewed and progressed at week 3 according to the participant's functional status.

Behavioral: Structured Home Exercise Program

Interventions

Otago Home Exercise Program BEHAVIORAL

nce exercises designed to improve lower extremity muscle strength, balance, functional mobility, and fall-related outcomes. Participants will perform the program 3 times per week for 6 weeks, with each session lasting approximately 40 minutes. The program will be reviewed and progressed at week 3.

Otago Home Exercise Program

Structured Home Exercise Program BEHAVIORAL

The structured home exercise program is a home-based exercise intervention including spinal stabilization exercises and stretching and strengthening exercises targeting the ankle plantar flexor and dorsiflexor muscles, quadriceps, lumbar extensor muscles, pectoral muscles, and hamstring muscles. Participants will perform the program 3 times per week for 6 weeks, with each session lasting approximately 40 minutes. The program will be reviewed and progressed at week 3.

Structured Home Exercise Program

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of Parkinson disease confirmed by a neurologist
• Hoehn and Yahr stage 3 or 4 Parkinson disease
• Diagnosis of Parkinson disease for at least 5 years
• Willingness to participate in the study and provide written informed consent
• Ability to walk independently or with minimal assistance
• Mini-Mental State Examination score \>24

You may not qualify if:

• Balance or gait impairment due to causes other than Parkinson disease, such as severe orthopedic problems or another neurological disease
• Red flags suggestive of Parkinson-plus syndromes, such as symmetric onset, early falls, early-onset dementia, or gaze palsy
• History of serious fall-related injury or surgery within the last 6 months
• Any additional health condition that would prevent participation in the exercise program during the study period

Sponsors & Collaborators

• Uludag University: lead

Study Sites (1)

Hatay Mustafa Kemal University

Hatay, Antakya, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Parkinson Disease; Motor Activity

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Behavior

Central Study Contacts

Selim GÜNAY, Asst Prof

CONTACT

+90 539 462 8521; mgselim1@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asst. Prof.

Model Details: rcise Program group or the structured home exercise program group. Both interventions will be delivered as home-based exercise programs for 6 weeks.

Study Record Dates

• First Submitted: May 10, 2026
• First Posted: May 15, 2026
• Study Start: February 8, 2026
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: May 19, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)