NCT07588087

Brief Summary

This randomized controlled trial aims to compare the effects of scapular proprioceptive neuromuscular facilitation (PNF) alone versus PNF combined with latissimus dorsi myofascial release on pain, range of motion, and functional disability in patients with stage II adhesive capsulitis; a condition characterized by capsular stiffness, pain, and restricted shoulder mobility, with outcomes assessed using NPRS, goniometry, and SPADI over a 6-week intervention period.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
58

participants targeted

Target at P25-P50 for not_applicable

Timeline
0mo left

Started Apr 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress75%
Apr 2026Jun 2026

Study Start

First participant enrolled

April 5, 2026

Completed
27 days until next milestone

First Submitted

Initial submission to the registry

May 2, 2026

Completed
12 days until next milestone

First Posted

Study publicly available on registry

May 14, 2026

Completed
23 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 6, 2026

Expected
2 days until next milestone

Study Completion

Last participant's last visit for all outcomes

June 8, 2026

Last Updated

May 14, 2026

Status Verified

May 1, 2026

Enrollment Period

2 months

First QC Date

May 2, 2026

Last Update Submit

May 8, 2026

Conditions

Outcome Measures

Primary Outcomes (4)

  • Pain Intensity

    Numeric Pain rating scale(NPRS) will be used. It is the numeric version of visual analogue scale used to assess the intensity of pain. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme. it has moderate to excellent reliability and good validity

    baseline to 6 weeks

  • Shoulder Range of Motion (ROM)

    Measured using a universal goniometer. Shoulder flexion, abduction, external rotation, and internal rotation will be assessed at baseline and at 6 weeks.

    baseline to 6 weeks

  • Latissimus Dorsi Length Test

    It is used to check the tightness of latissimus dorsi muscle. The patient is in supine lying with knees bend and back flattened to the floor, arm elevated overhead. if there is tightness of this muscle person's unable to flexed his arm by 180° and compensated by arching its back also with the help of goniometer measurement starts with axis at the humeral head , stationary arm midline to the body and moveable arm parallel to the longitudinal axis of the humerus a normal full length muscle allows the arms to touch the table while shortened muscle not allow them to touch the table.

    baseline to 6 weeks

  • Shoulder Pain and Disability Index (SPADI)

    The Shoulder Pain and Disability Index (SPADI) is a self-administered questionnaire used to assess pain and functional disability associated with shoulder conditions. It consists of 13 items divided into two subscales: pain (5 items) and disability (8 items). Each item is scored on a scale from 0 to 10, where 0 indicates no pain or difficulty and 10 indicates the worst pain or maximum difficulty. The total score is calculated by averaging the scores of both subscales and converting them into a percentage ranging from 0 to 100, with higher scores indicating greater pain and disability.

    baseline to 6 weeks

Study Arms (2)

Latissimus dorsi myofascial release and Scapular PNF hold-relax technique. ( Experimental)

EXPERIMENTAL

Received latissimus dorsi myofascial release (10-15 minutes, sustained pressure with 90-120 sec holds) combined with scapular PNF hold-relax (posterior elevation-anterior depression pattern; 3 sets × 5 reps, 5-7 sec contraction, 10-15 sec stretch).

Other: Myofascial release+ Scapular Proprioceptive Neuromuscular Facilitation (PNF) hold-relax technique

Scapular PNF hold-relax only (control)

ACTIVE COMPARATOR

Received scapular PNF hold-relax only (same pattern and dosage: 3 sets × 5 reps, 5-7 sec contraction, 10-15 sec stretch),

Other: Scapular PNF hold-relax only

Interventions

Participants in the experimental group will receive a combination of latissimus dorsi myofascial release (MFR) and scapular proprioceptive neuromuscular facilitation (PNF) using the hold-relax technique. Myofascial release will be applied to the latissimus dorsi muscle with the patient positioned in side-lying (affected side up) or supine with the shoulder in flexion. The therapist will apply slow, sustained pressure along the posterior axillary fold and lateral border of the scapula, following the muscle fibers toward the thoracolumbar fascia. The technique will include sustained pressure, longitudinal gliding, and passive shoulder elevation until a tissue resistance barrier is reached. Each stretch will be maintained for 90-120 seconds, with a total MFR duration of approximately 10-15 minutes per session. Following MFR, scapular PNF will be performed using the posterior elevation to anterior depression pattern. The hold-relax technique will involve isometric contractions of 5-7 seco

Latissimus dorsi myofascial release and Scapular PNF hold-relax technique. ( Experimental)

Participants in the control group will receive scapular proprioceptive neuromuscular facilitation (PNF) using the hold-relax technique without the addition of myofascial release. The intervention will follow the scapular posterior elevation to anterior depression pattern. Each repetition will include an isometric contraction lasting 5-7 seconds followed by a passive stretch of 10-15 seconds. A total of 3 sets with 5 repetitions per set will be performed in each session, with an overall duration of approximately 20 minutes. In addition, a hot pack will be applied to the affected area for 10-15 minutes prior to the exercise session to promote muscle relaxation. Treatment sessions will be conducted three times per week for a duration of 6 weeks.

Scapular PNF hold-relax only (control)

Eligibility Criteria

Age35 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • \. Age between 35 and 70 years.
  • Both male and female participants.
  • Stiffening (Stage II) phase of frozen shoulder.
  • Pain intensity ≥ 4/10 on NPRS during shoulder movement.
  • Unilateral shoulder involvement.
  • Presence of capsular pattern:ER \> ABD \> IR limitation
  • Apley's Scratch Test
  • Limited both ROMs
  • Symptom duration between 3 and 9 months.(Di Mascio et al., 2024)

You may not qualify if:

  • Secondary adhesive capsulitis due to trauma or surgery
  • History of shoulder fracture or dislocation.
  • Bilateral frozen shoulder.
  • Active systemic inflammatory or neurological disease
  • Recent intra-articular corticosteroid injection (within last 3 months)
  • Current anticoagulation therapy or bleeding disorders.
  • Pregnant females.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

• Ibadat international hospital • Shaafi international hospital • South East hospital • Fauji Foundation hospital

Islamabad, Punjab Province, 44000, Pakistan

RECRUITING

Related Publications (11)

  • Teoli D, Sanvictores T, An J. SWOT Analysis. 2023 Sep 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK537302/

    PMID: 30725987BACKGROUND
  • Su S, Guo Y, Parnitzke B, Poerio T, Derosa J. A Voltage-Controlled Strategy for Modular Shono-Type Amination. J Am Chem Soc. 2024 Oct 23;146(42):28663-28668. doi: 10.1021/jacs.4c12520. Epub 2024 Oct 14.

    PMID: 39401528BACKGROUND
  • Elnaggar RK, Elbanna MF, Mahmoud WS, Alqahtani BA. Plyometric exercises: subsequent changes of weight-bearing symmetry, muscle strength and walking performance in children with unilateral cerebral palsy. J Musculoskelet Neuronal Interact. 2019 Dec 1;19(4):507-515.

    PMID: 31789302BACKGROUND
  • Roach KE, Budiman-Mak E, Songsiridej N, Lertratanakul Y. Development of a shoulder pain and disability index. Arthritis Care Res. 1991 Dec;4(4):143-9.

    PMID: 11188601BACKGROUND
  • Page MJ, Green S, Kramer S, Johnston RV, McBain B, Chau M, Buchbinder R. Manual therapy and exercise for adhesive capsulitis (frozen shoulder). Cochrane Database Syst Rev. 2014 Aug 26;2014(8):CD011275. doi: 10.1002/14651858.CD011275.

    PMID: 25157702BACKGROUND
  • Fehd HM, Seiffert AE. Looking at the center of the targets helps multiple object tracking. J Vis. 2010 Apr 28;10(4):19.1-13. doi: 10.1167/10.4.19.

    PMID: 20465338BACKGROUND
  • Harnett G, Collins M. Nursing in rural, remote and isolated settings: a literature review. Rural Remote Health. 2023 Jan;23(1):8159. doi: 10.22605/RRH8159. Epub 2023 Jan 10.

    PMID: 36802815BACKGROUND
  • Khaled N, Kalbarczyk A, Zavala E, Rahman A, de Boer M, Chakraborty B, Rahman H, Ali H, Haque R, Ayesha K, Siddiqua TJ, Afsana K, Christian P, Thorne-Lyman AL. A formative study of the sociocultural influences on dietary behaviours during pregnancy in rural Bangladesh. Matern Child Nutr. 2024 Oct;20 Suppl 6(Suppl 6):e13713. doi: 10.1111/mcn.13713. Epub 2024 Aug 30.

    PMID: 39212336BACKGROUND
  • Zhang W, Xia K, Feng Z, Qin Y, Zhou Y, Feng G, Zhu H, Yao Q. Tomato plant growth promotion and drought tolerance conferred by three arbuscular mycorrhizal fungi is mediated by lipid metabolism. Plant Physiol Biochem. 2024 Mar;208:108478. doi: 10.1016/j.plaphy.2024.108478. Epub 2024 Feb 28.

    PMID: 38430785BACKGROUND
  • Thayaparan T, Petrovic RM, Achkova DY, Zabinski T, Davies DM, Klampatsa A, Parente-Pereira AC, Whilding LM, van der Stegen SJ, Woodman N, Sheaff M, Cochran JR, Spicer JF, Maher J. CAR T-cell immunotherapy of MET-expressing malignant mesothelioma. Oncoimmunology. 2017 Aug 14;6(12):e1363137. doi: 10.1080/2162402X.2017.1363137. eCollection 2017.

    PMID: 29209570BACKGROUND
  • Ahearn N, McCann PA, Tasker A, Sarangi PP. The influence of rotator cuff pathology on functional outcome in total shoulder replacement. Int J Shoulder Surg. 2013 Oct;7(4):127-31. doi: 10.4103/0973-6042.123509.

    PMID: 24403759BACKGROUND

MeSH Terms

Conditions

Bursitis

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal Diseases

Central Study Contacts

Hufsa Naseer, DPT, MS-PT MSK

CONTACT

Fatima Amjad, DPT, MS-PT Sports, PHD Scholar

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
Outcome assessor will be blinded to group allocation.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Two-arm parallel group randomized controlled trial
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 2, 2026

First Posted

May 14, 2026

Study Start

April 5, 2026

Primary Completion (Estimated)

June 6, 2026

Study Completion (Estimated)

June 8, 2026

Last Updated

May 14, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Locations