Prospective Clinical Database Construction for Liver Cancer Diagnosis and Treatment

NCT07587216 | Recruiting DMC

• 1 other identifier: LIC-PRO-2026
• Study Type: observational
• Target: 800
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a prospective, observational, real-world cohort study. We aim to establish a prospective database in the Department of Hepatobiliary and Pancreatic Surgery, systematically collecting and integrating patients' full-course diagnostic and therapeutic information along with long-term outcomes. This will enable objective evaluation of prognosis and treatment efficacy in real-world clinical practice, while providing a data foundation and evidence support for subsequent optimization of clinical decision-makin

Conditions

Liver Cancer (Primary and Metastatic)

Outcome Measures

Primary Outcomes (1)

• overall survival

  From date of treatment until the date of death from any cause, assessed up to 100 months

Secondary Outcomes (1)

• Incidence of Adverse Events

  Within 30 days following interventions

Study Arms (2)

Liver resection group

Procedure: liver resection

Non-surgery group

Drug: Systemic therapy combined with locoregional interventions

Interventions

liver resection PROCEDURE

Patients undergo liver resection for tumor.

Liver resection group

Systemic therapy combined with locoregional interventions DRUG

Patients recieve PD-1 inhibitors combined with targeted drugs and locoregional interventions

Non-surgery group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with liver cancer

You may qualify if:

• Male or female aged ≥18 years at the time of signing the informed consent form;
• Clinically or histologically confirmed diagnosis of liver cancer;
• Recieving treatment and follow-up in Tongji Hospital

Sponsors & Collaborators

• Tongji Hospital: lead

Study Sites (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China

RECRUITING

MeSH Terms

Conditions

Liver Neoplasms; Neoplasm Metastasis

Interventions

Hepatectomy

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Liver Diseases; Neoplastic Processes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Digestive System Surgical Procedures; Surgical Procedures, Operative

Central Study Contacts

Qi Cheng, M.D.

CONTACT

13871459541; chengqi@hust.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Director of Hepatobiliary and Pancreatic Surgery Department

Study Record Dates

• First Submitted: May 8, 2026
• First Posted: May 14, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2029
• Last Updated: May 14, 2026

Record last verified: 2026-05

Locations

CN (1)