A Crossover Exploratory Study of NatureU Cheers Friends Curcumin on Acute Alcohol Hangover Symptoms

NCT07585825 | Completed

• 1 other identifier: 2024060001
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

This was a single-center, open-label, exploratory crossover study evaluating acute hangover symptoms after use of NatureU Cheers Friends Curcumin compared with an active comparator product in healthy adult men. Participants completed two independent test-food sessions separated by at least 48 hours. Sixteen participants were recruited, 12 were screened and enrolled, and 12 were included in the effectiveness analysis. In the control session, participants took Herbsense hangover relief tablets 30 minutes before alcohol intake. In the NatureU Cheers Friends Curcumin session, participants took NatureU Cheers Friends Curcumin 30 minutes before alcohol intake. The main outcome was the Acute Hangover Scale (AHS) assessed the morning after each test session. Safety was monitored during the test procedures.

Conditions

Alcohol Hangover; Alcohol Misuse

Keywords

NatureU Cheers Friends Curcumin; hangover; acute hangover scale; functional food; magnolia bark; milk thistle; turmeric

Outcome Measures

Primary Outcomes (1)

• Difference in Acute Hangover Scale Total Score Between NatureU Cheers Friends Curcumin and Comparator Product

  The Acute Hangover Scale includes nine items scored from 0 to 7, with higher scores indicating more severe hangover symptoms. The primary endpoint was the difference in total AHS score after NatureU Cheers Friends Curcumin compared with the comparator product.

  12 hours after alcohol intake in each test-food session

Secondary Outcomes (1)

• Difference in Individual Acute Hangover Scale Item Scores Between NatureU Cheers Friends Curcumin and Comparator Product

  12 hours after alcohol intake in each test-food session

Other Outcomes (1)

• Safety and Tolerability During Test-Food Sessions

  Baseline, 30 minutes, 60 minutes, and 120 minutes after alcohol intake during each test session

Study Arms (2)

NatureU Cheers Friends Curcumin

EXPERIMENTAL

Participants received NatureU Cheers Friends Curcumin, three tablets orally 30 minutes before alcohol intake.

Dietary Supplement: NatureU Cheers Friends Curcumin

Herbsense Hangover Relief Tablet

ACTIVE COMPARATOR

Participants received Herbsense hangover relief tablets, two tablets orally 30 minutes before alcohol intake.

Dietary Supplement: Herbsense Hangover Relief Tablet

Interventions

NatureU Cheers Friends Curcumin DIETARY_SUPPLEMENT

NatureU Cheers Friends Curcumin is an oral functional food product containing magnolia bark extract, milk thistle extract, high-concentration turmeric, and related ingredients. Participants took three tablets 30 minutes before alcohol intake.

NatureU Cheers Friends Curcumin

Herbsense Hangover Relief Tablet DIETARY_SUPPLEMENT

The comparator product was Herbsense hangover relief tablet. Participants took two tablets 30 minutes before alcohol intake during the comparator session.

Herbsense Hangover Relief Tablet

Eligibility Criteria

• Age: 18 Years - 44 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Signed informed consent before the study and understood the study content, procedures, and possible adverse reactions.
• Healthy adult man aged 20 to 48 years, inclusive.
• Normal social drinking lifestyle and no alcohol dependence.
• Aspartate aminotransferase and alanine aminotransferase values within two standard deviations of the normal range.
• Able to maintain normal healthy routines during the study.
• Able to avoid other interfering supplements for 2 weeks before and during the study.
• Abstained from alcohol for 24 hours before the study.
• Abstained from caffeinated beverages, including coffee, tea, and energy drinks, for 12 hours before the study.

You may not qualify if:

• Known allergy or hypersensitivity to product ingredients, including magnolia bark, milk thistle extract, turmeric, or alcohol.
• History of multiple drug or food allergies.
• Acute or chronic inflammatory disease, including influenza A, within the previous month.
• Hypertension.
• Participation in any other clinical trial within 1 month before first use of the study product.
• Clinically significant gastrointestinal, renal, hepatic, neurologic, hematologic, endocrine, oncologic, pulmonary, immune, psychiatric, cardiovascular, cerebrovascular, or metabolic disease within the previous 6 months.
• Acute illness or concomitant medication use from screening to first use of the study product.
• Surgery within the previous 3 months.
• Blood donation or major blood loss greater than 450 mL within the previous 3 months.
• Difficulty swallowing.
• Use of prescription or non-prescription medications affecting nutritional supplements or alcohol metabolism.
• Any other factor judged by the investigator to make participation inappropriate.

Sponsors & Collaborators

• OmniSolutions Laboratory Holdings Limited: lead

Study Sites (1)

Dao County People's Hospital

Yongzhou, Hunan, 425300, China

Location

Study Officials

• Luke Law, Dr

  OmniSolutions Laboratory Holdings Limited

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Masking Details: The study was open-label with no masking.
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Participants completed two independent test-food sessions, one with the comparator product and one with NatureU Cheers Friends Curcumin, separated by at least 48 hours.

Study Record Dates

• First Submitted: April 30, 2026
• First Posted: May 14, 2026
• Study Start: June 20, 2024
• Primary Completion: June 21, 2024
• Study Completion: June 21, 2024
• Last Updated: May 14, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)