SWedish Intensive Care Biobank

NCT07582601 | Not Yet Recruiting DMC

• 2 other identifiers: SWIC-B2024-04531-01
• Study Type: observational
• Target: 25,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to understand the genetic and molecular risk factors for developing critical illness in adult intensive care unit (ICU) patients in Sweden. The main questions it aims to answer are: Which genetic variants are associated with increased risk of critical illness from conditions such as infections, sepsis, and organ failure? Can circulating proteins and metabolites mediate the effect of genetic risk factors on the severity of illness? Participants will: Provide blood samples at ICU admission and again 3-6 months after discharge Consent to genetic analysis and data linkage with national health registries Have their ICU treatment and outcomes followed using registry and clinical data This study aims to build a national infrastructure for rapid sample collection and analysis that can also support research in future pandemics.

Conditions

Any Condition Underlying Critical Illness

Keywords

critical illness; shock; sepsis; heart failure; ards; acute kidney injury; infection; organ failure; intensive care

Outcome Measures

Primary Outcomes (2)

• 30 day mortality

  Death of any cause within 30 days of ICU admission

  30 days

• ICU admission

  ICU admission for any specific cause

  30 days

Study Arms (1)

ICU admission

Any patient admitted to ICU in Sweden

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Any patient admitted to intensive care at a hospital in Sweden

You may qualify if:

• Adults admitted to intensive care in Sweden

You may not qualify if:

• Non adults
• Not admitted to intensive care

Sponsors & Collaborators

• Uppsala University: lead

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood and plasma

MeSH Terms

Conditions

Critical Illness; Shock; Sepsis; Heart Failure; Acute Lung Injury; Acute Kidney Injury; Infections

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Systemic Inflammatory Response Syndrome; Inflammation; Heart Diseases; Cardiovascular Diseases; Lung Injury; Lung Diseases; Respiratory Tract Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

Michael Marks-Hultström, MD PhD

CONTACT

0186110000; michael.hultstrom@mcb.uu.se

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: November 24, 2025
• First Posted: May 13, 2026
• Study Start (Estimated): January 1, 2027
• Primary Completion (Estimated): December 30, 2035
• Study Completion (Estimated): December 30, 2035
• Last Updated: May 13, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share