Risk Factors for Hypoparathyroidism Following Thyroidectomy

NCT07582562 | Recruiting

• 1 other identifier: TartuUH-ETCH_403/T-13_1
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of this observational study is to identify the risk factors for post-thyroidectomy hypoparathyroidism in Estonia and to determine whether the magnesium level plays a significant role in the development of hypoparathyroidism. The main questions it aims to answer are:

• How common is post-thyroidectomy hypoparathyroidism in Estonia?
• What are the most significant risk factors for the development of post-thyroidectomy hypoparathyroidism in Estonia?
• Are magnesium levels a risk factor for the development of hypoparathyroidism? Participants will be asked to answer a questionnaire about risk factors. The study collects data on risk factors for hypoparathyroidism following thyroid surgery, including patient questionnaires and comorbidities, pre- and postoperative laboratory tests and surgery-related risk factors.

Conditions

Post-Surgical Hypoparathyroidism

Keywords

thyroidectomy; hypoparathyroidism; risk factors

Outcome Measures

Primary Outcomes (1)

• postoperative early hypoparathyroidism

  Incidence of early post-thyroidectomy hypoparathyroidism, based on serum PTH levels measured on the morning of the first postoperative day

  first postoperative day

Secondary Outcomes (3)

• Risk factor assessment of post-thyroidectomy hypoparathyroidism

  Preoperative and intraoperative periods

• Serum magnesium levels as predictors of post-thyroidectomy hypoparathyroidism

  Preoperative (baseline) and postoperative day 1; hypoparathyroidism assessed within 24 hours postoperatively

• Postoperative permanent hypoparathyroidism

  12 months after surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients over the age of 18 at Tartu University Hospital and East Tallinn Central Hospital who are undergoing surgery involving both lobes of the thyroid gland (thyroidectomy, "near-total" thyroidectomy, subtotal thyroidectomy, and "completed" thyroidectomy), and who provide informed consent for this.

You may qualify if:

• patients over the age of 18 undergoing surgery involving both lobes of the thyroid gland (thyroidectomy, "near-total" thyroidectomy, subtotal thyroidectomy, and "completed" thyroidectomy)
• patients who are capable of giving informed consent

You may not qualify if:

• patients undergoing unilateral thyroid lobectomy only
• patients with concomitant hyperparathyroidism undergoing simultaneous thyroidectomy and parathyroidectomy for a parathyroid adenoma

Sponsors & Collaborators

• Tartu University Hospital: lead
• East Tallinn Central Hospital: collaborator

Study Sites (2)

East Tallinn Central Hospital

Tallinn, Estonia

RECRUITING

Tartu University Hospital

Tartu, Estonia

RECRUITING

MeSH Terms

Conditions

Hypoparathyroidism

Condition Hierarchy (Ancestors)

Parathyroid Diseases; Endocrine System Diseases

Central Study Contacts

Hanna Hollman, MD

CONTACT

+37259037517; hanna.hollman@ut.ee

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: general surgeon, PhD

Study Record Dates

• First Submitted: April 21, 2026
• First Posted: May 13, 2026
• Study Start: October 13, 2025
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): December 1, 2028
• Last Updated: May 13, 2026

Record last verified: 2026-05

Locations

ES (2)