Perioperative Prospective Follow Up Of Cannabis Consumers and Discrepancy Use

NCT07582445 | Active Not Recruiting

• 1 other identifier: 0001-25-HMO
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

This study includes a prospective non interventional study that aims to asses the prevalence of cannabis use among patients undergoing elective surgery and evaluates its impact on perioperative outcomes, including pain, opioid consumption, nausea, anxiety, and sleep disturbances. A matched control cohort will provide comparative data. Discrepancies between self-reported and objectively measured cannabis use will be assessed using blood samples and urine samples. Participants will be requested to complete preoperative and postoperative questionnaires on days 1, 2, 3, 7, and 30 to monitor cannabis use and perioperative symptoms. This study aims to clarify the perioperative effects of cannabis use and the accuracy of patient-reported consumption.

Conditions

Discrepancy With Clinical Examination; Cannabinoid

Outcome Measures

Primary Outcomes (2)

• discrepancy percentage between reported cannabis users and actual cannabis usage among patients undergoing elective surgery.

  up to 7 days

• Use of Cannabis

  Doasge Use of Cannabis

  up to 7 days postopertively

Secondary Outcomes (1)

• Pain levels during surgery as assesed using VAS

  up to 7 days

Study Arms (2)

Study cohort: patients undergoing elective surgery who use cannabis.

Control cohort: patients undergoing elective surgery who do not regularly use cannabis.

Other: This study is non interventional and will only include filling in questionnaires and providing blood and urine sample

control group

Patients undergoing elective surgery who do not use cannabis regularly

Other: This study is non interventional and will only include filling in questionnaires and providing blood and urine sample

Interventions

This study is non interventional and will only include filling in questionnaires and providing blood and urine sample OTHER

urine sample

Study cohort: patients undergoing elective surgery who use cannabis.; control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of patients scheduled to undergo elective surgery. This will include individuals who regularly use cannabis, as well as a matched control cohort with similar demographics who do not use cannabis.

You may qualify if:

• Patients who use cannabis and are scheduled to undergo elective surgery.
• A matched control cohort of patients with similar demographics who are also scheduled for elective surgery.

You may not qualify if:

• None

Sponsors & Collaborators

• Hadassah Medical Organization: lead

Study Sites (1)

Hadassah Medical Center

Jerusalem, 9210141, Israel

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Urine and blood samples

MeSH Terms

Interventions

Surveys and Questionnaires

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Elyad Davidson, MD

  Hadassah medical center/ Hebrew univeristy

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chair of pain clinic

Study Record Dates

• First Submitted: September 7, 2025
• First Posted: May 12, 2026
• Study Start: May 6, 2026
• Primary Completion (Estimated): July 10, 2026
• Study Completion (Estimated): December 10, 2027
• Last Updated: May 12, 2026

Record last verified: 2026-05

Locations

IL (1)