How Can Different Forms of Strengthening Exercises Affect the Muscular Tissue and Its Chemical Markers in Children With Duchenne Muscular Dystrophy

NCT07581743 | Not Yet Recruiting

• 1 other identifier: PUA0320234303090
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The treatment of patients diagnosed with DMD needs to be multidisciplinary, judicious, and always focused on the patient's well-being. Physiotherapy and occupational therapy are very often standard care. Physiotherapy is regarded as crucial for the success of treatment, since it has achieved good results in the short term, such as maintaining the autonomy of these individuals . Physical activity is another method that has been used to treat DMD. Studies have used physical exercise in individuals with DMD in order to decrease muscle deterioration, muscle contractures, and bone fractures, and to increase the time of functional independence

Conditions

Duchene Muscular Dystrophy

Outcome Measures

Primary Outcomes (3)

• Creatine-kinase (CK)

  8 weeks

• Six-minute walk test

  8 weeks

• Muscle strength

  8 weeks

Study Arms (3)

Strengthening exercises

EXPERIMENTAL

Other: strengthening exercises

Low-Intensity Exercise

EXPERIMENTAL

Other: Low-Intensity Exercise Protocol

Control group

ACTIVE COMPARATOR

Other: traditional physical therapy program

Interventions

strengthening exercises OTHER

Concentric strengthening exercises: involves the muscle producing tension and shortening to move a load Isometric strengthening exercises: occurs when a muscle produces tension without a change in muscle length. Isometric contractions involve sarcomere shortening and increasing muscle tension, but do not move a load Eccentric strengthening exercises: occurs when the muscle tension produced is less than the load and a muscle lengthens while under tension

Strengthening exercises

traditional physical therapy program OTHER

traditional physical therapy program to improve strength

Control group

Low-Intensity Exercise Protocol OTHER

The children were trained 3 times per week for 8 weeks on a treadmill without inclination, with speed and time programmed and adapted for this purpose. The length of each training activity was 30 min (Andersen et al. 2013; Markert et al. 2012). The children were acclimated to the treadmill for 7 days before the beginning of the training program, with a speed of 4 m/min, in order to minimize the stress caused by the different environment.

Low-Intensity Exercise

Eligibility Criteria

• Age: 6 Years - 10 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• DD,
• aging from 6 To 10

You may not qualify if:

• able to understand order

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Reham

Giza, Egypt

Location

Central Study Contacts

Reham Alsakhawi

CONTACT

00966504182628; rsm211_pt@cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 6, 2026
• First Posted: May 12, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): August 15, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: May 12, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)