Data-Driven Lay First Responder Program in Cameroon

NCT07581327 | Not Yet Recruiting

• 1 other identifier: K01TW012689
• Study Type: interventional
• Target: 1,812
• Locations: 1 country
• Sites: 1

Brief Summary

Cameroon experiences a high burden of injury-related morbidity and mortality and currently lacks a formal pre-hospital care system. Lay First Responder (LFR) programs have been implemented in several low-and middle-income countries to improve early injury care by training non-medical community members with high exposure to injury, such as commercial drivers, in basic first aid and safe transport of injured patients. The study aims to implement and evaluate a data-driven, context-adapted LFR program in Cameroon using an implementation science approach. Quantitative trauma registry data and qualitative stakeholder interviews will be used to adapt the LFR curriculum to local injury patterns and care gaps. LFR program implementation will be associated with increased chances of survival on presentation and improved trauma outcomes. The study is an interrupted time series evaluation of an LFR intervention where prehospital care rates and clinical patterns in the Cameroon Trauma Registry (CTR) patients at Limbe Regional hospital will be compared between historical pre-implementation controls and post-implementation of a data-driven lay first responder training program (the intervention).

Conditions

Trauma; Injury

Keywords

Lay First Resposnder; Trauma; Pre-Hospital care; Road Traffic Injury; By-stander response; Trauma systems; Emergency Care

Outcome Measures

Primary Outcomes (1)

• Prehospital care rate

  Proportion of hospitalized trauma patients who received prehospital care prior to arrival at participating hospitals, compared between pre- and post implementation LFR cohorts.

  From enrollment through the 18-month post implementation period.

Secondary Outcomes (7)

• Systolic blood pressure at presentation

  From enrollment through the 18-month post implementation period.

• Respiratory rate greater than 8 and less than 20 breaths per minute

  From enrollment through the 18-month post-implementation period

• Proportion of trauma patients with heart rate between 60 and 100 beats per minute

  From enrollment through the 18-month post implementation period.

• In-hospital mortality

  From enrollment through the 18-month post-implementation period.

• 24-hour mortality

  From enrollment through the 18-month post implementation period.

Study Arms (2)

Pre-LFR implementation CTR cohort

NO INTERVENTION

Historic data of trauma patients enrolled during an 18-month pre-implementation period in Limbe Regional Hospital before the LFR training program commences.

Post-LFR implementation CTR cohort

EXPERIMENTAL

Trauma patients enrolled in the 18- month post-implementation period in Limbe Regional Hospital after the 3-month LFR provider training program and transition period has ended.

Behavioral: Lay First Responder (LFR) training

Interventions

Lay First Responder (LFR) training BEHAVIORAL

Training of LFR providers using a data driven, pretested curriculum adapted for the Cameroon context over a 3-month training and transition period.

Post-LFR implementation CTR cohort

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Trauma patients presenting to Limbe Regional Hospital and enrolled in the Cameroon Trauma Registry

You may not qualify if:

• \- Trauma patients not included in the Cameroon trauma registry at Limbe regional hospital.

Sponsors & Collaborators

• Sabrinah Christie: lead
• Fogarty International Center of the National Institute of Health: collaborator
• University of Buea: collaborator
• University of California, Los Angeles: collaborator

Study Sites (1)

Limbe Health District

Limbe, Southwest, Cameroon

Location

MeSH Terms

Conditions

Wounds and Injuries

Central Study Contacts

S.Ariane Christie, BA, MD

CONTACT

808-430-9678; s.ariane.christie@gmail.com

Isaac Obeng-Gyasi, MBChB, MPH

CONTACT

202-500-4230; iobeng@mednet.ucla.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor of Surgery

Model Details: The study is an interrupted time series evaluation of a Lay First Responder (LFR) training program where prehospital care rates and clinical patterns of injured Cameroon Trauma Registry patients at Limbe Regional hospital will be compared between historical pre-implementation group and post- implementation cohort of the LFR training (the intervention).

Study Record Dates

• First Submitted: April 15, 2026
• First Posted: May 12, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): June 1, 2028
• Study Completion (Estimated): September 1, 2028
• Last Updated: May 12, 2026

Record last verified: 2026-05

Locations

CA (1)