The REACT Study: REhabilitation and ACTivity in Allogenic Transplant

NCT07581093 | Not Yet Recruiting

• 1 other identifier: REACT
• Study Type: observational
• Target: 140
• Locations: 0 countries
• Sites: N/A

Brief Summary

A prospective, longitudinal cohort study will be conducted to evaluate the effects of treatment on the physical function of patients undergoing Allogeneic Hematopoeitic Stem Cell Transplant.

Conditions

Allogeneic Hematopoietic Stem Cell Transplant (Allo-HSCT)

Keywords

Stem Cell Transplantation; Physical Functional Performance; Physical Activity

Outcome Measures

Primary Outcomes (2)

• Change in Physical Function

  The Short Physical Performance Battery will be used to assess physical function. Scores range from 0 to 12, with higher scores indicating better physical performance and functional mobility.

  Pre-treatment (T0), Pre-admission (T1), 3 months post-transplant (T2), 6 months post-transplant (T3), 1 year post-transplant assessment (T4).

• Change in Physical Function

  The World Health Organization Disability Schedule 2.0 will be used to assess any change in health and disability. A 12-item version will be used with each item rated on a 5-point Likert scale Higher scores indicate greater disability ie. minimum: 12 (no disability) and maximum: 60 (complete/extreme disability)

  Pre-treatment (T0), Pre-admission (T1), 3 months post-transplant (T2), 6 months post-transplant (T3), 1 year post-transplant assessment (T4).

Secondary Outcomes (9)

• Change in Aerobic Fitness

  Pre-treatment (T0), Pre-admission (T1), 3 months post-transplant (T2), 6 months post-transplant (T3), 1 year post-transplant assessment (T4).

• Change in Muscle Strength

  Pre-treatment (T0), Pre-admission (T1), 3 months post-transplant (T2), 6 months post-transplant (T3), 1 year post-transplant assessment (T4).

• Change in Physical Activity Levels

  Pre-treatment (T0), Pre-admission (T1), 3 months post-transplant (T2), 6 months post-transplant (T3), 1 year post-transplant assessment (T4).

• Change in Quality of Life

  Pre-treatment (T0), Pre-admission (T1), 3 months post-transplant (T2), 6 months post-transplant (T3), 1 year post-transplant assessment (T4).

• Change in Fatigue Levels

  Pre-treatment (T0), Pre-admission (T1), 3 months post-transplant (T2), 6 months post-transplant (T3), 1 year post-transplant assessment (T4).

Other Outcomes (1)

• Qualitative Feedback

  Pre-treatment (T0), Pre-admission (T1), 3 months post-transplant (T2), 6 months post-transplant (T3), 1 year post-transplant assessment (T4).

Study Arms (1)

Patients undergoing haematopoeitic stem cell transplant

Patients who are listed for allogeneic stem cell transplant.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing allogeneic stem cell transplant.

You may qualify if:

• Patients who are listed for allogeneic stem cell transplant.
• Ability to provide written informed consent
• Over 18 years old

You may not qualify if:

• Nil

Sponsors & Collaborators

• University of Dublin, Trinity College: lead
• Health Research Board, Ireland: collaborator

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Central Study Contacts

Grainne Sheill, PhD

CONTACT

+353 879403733; sheillg@tcd.ie

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 26, 2026
• First Posted: May 12, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 28, 2029
• Study Completion (Estimated): December 28, 2029
• Last Updated: May 12, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share