Mobile Technology to Measure Knee Health in Osteoarthritis

NCT07580222 | Recruiting

• 3 other identifiers: RRD8-005-24W66791IK1RD000707
• Study Type: observational
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

Veterans face a high prevalence of knee osteoarthritis (OA), but current diagnostic methods often miss early stages when interventions are more effective. This project will evaluate smartphone-based motion capture via OpenCap to measure joint mechanics in knee OA patients during functional activities, comparing its performance to a conventional motion capture system, patient-reported symptoms, and knee joint structure. The findings will have the potential to enable clinicians to trial OpenCap in its current form, provide insights into tracking joint health, and guide refinements to advance toward earlier diagnosis of knee OA by complementing symptom assessments with measures of joint mechanics.

Conditions

Osteoarthritis, Knee

Outcome Measures

Primary Outcomes (1)

• Knee flexion angle

  Knee flexion angle extracted from functional activities (e.g., walking, chair-to-stand)

  Baseline and Week 1

Secondary Outcomes (1)

• Knee flexion moment

  Baseline and Week 1

Other Outcomes (3)

• Western Ontario and McMaster Universities Osteoarthritis Index (Transformed)

  Baseline and Week 1

• Duration of 40-meter fast walk test

  Baseline or Week 1

• Repetitions for 30-second chair-to-stand test

  Baseline or Week 1

Study Arms (1)

Knee OA

Adults who were previously diagnosed with early knee osteoarthritis, enrolled in Precision Assessment of Platelet Rich Plasma for Joint Preservation study (NCT03460236), and able and willing to participate in the follow-up assessment.

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals who were diagnosed with early knee osteoarthritis and had a history of being elected to receive injection treatment

You may qualify if:

• Veteran and non-Veterans
• males and females
• diagnosed with early knee osteoarthritis
• qualified for and participated in the Precision Assessment of Platelet Rich Plasma for Joint Preservation study (ClinicalTrials.gov ID: NCT03460236)
• able and willing to provide informed consent for follow-up study

You may not qualify if:

• symptomatic OA in joints other than the knee in the lower body
• joint replacement
• rheumatic disease
• BMI \> 35 kg/m\^2
• severe systematic disease defined as American Society of Anesthesiologists (ASA) 3 or above
• pregnant or intending to become pregnant during the study

Sponsors & Collaborators

• VA Office of Research and Development: lead

Study Sites (1)

VA Palo Alto Health Care System, Palo Alto, CA

Palo Alto, California, 94304-1207, United States

RECRUITING

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Jade He, PhD

  VA Palo Alto Health Care System, Palo Alto, CA

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jade He, PhD

CONTACT

(650) 493-5000; Jade.He@va.gov

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: FED
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 8, 2026
• First Posted: May 12, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): September 30, 2027
• Study Completion (Estimated): March 31, 2028
• Last Updated: May 12, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)