Familial Risk of AAA in Sweden

NCT07577128 | Active Not Recruiting

• 1 other identifier: Karolinska Institutet
• Study Type: observational
• Target: 900,000
• Locations: 1 country
• Sites: 1

Brief Summary

The aim is to study the prevalence of abdominal aortic aneurysm in first degree relatives and the risk to develop AAA in individuals with heredity for AAA compared with the population ( without heredity for AAA).The study i based on national registers in Sweden with high coverage and capacity of linkage between different registers.

Conditions

Abdominal Aneurysm; Aortic Aneurysm; Aortic Aneurysm Abdominal

Keywords

Abdominal aortic aneurysm; Heredity; Screening; Familial risk

Outcome Measures

Primary Outcomes (1)

• The Familial risk of Abdominal Aortic Aneurysm in first-degree relatives compared with the population.

  To describe the risk for female and male first-degree relatives (FDR) to female and male persons diagnosed with AAA (index persons) to develop a diagnosed AAA, compared to the population.

  Through study completion, data spanning 1952 to 2024

Secondary Outcomes (1)

• Heredity as a risk factor for AAA

  At time of AAA diagnosis, cases diagnosed between 2010 and 2024.

Study Arms (4)

Index cases

Individuals with diagnosed abdominal aortic aneurysm during 2010- 2024

First-degree relatives to index cases

First- degree relatives to index cases with AAA. Siblings, Parents, Children identified through the Multigeneration register.

Index controls

Control population to index cases based on sex, age, region and income.

First-degree relatives of controls

First-degree relatives of the control population (index controls). Individuals without familial AAA.

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Individuals with the diagnose AAA or the cause of death AAA in Sweden 2010-2024. The first-degree relatives have been identified through the Swedish multigeneration register and then a register based identifiaction if having AAA or not. All men and female over 45 years old are included.

You may not qualify if:

• younger than 45 years.

Sponsors & Collaborators

• Karolinska University Hospital: lead
• Karolinska Institutet: collaborator
• Swedish Heart Lung Foundation: collaborator

Study Sites (1)

Karolinska Institutet

Stockholm, Sweden

Location

MeSH Terms

Conditions

Aortic Aneurysm, Abdominal; Aortic Aneurysm

Condition Hierarchy (Ancestors)

Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Week
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Adjunct Professor of Vascular Surgery

Study Record Dates

• First Submitted: April 15, 2026
• First Posted: May 11, 2026
• Study Start: January 1, 2010
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): December 31, 2028
• Last Updated: May 11, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)