Grape Seed Powder and Vitamin C Supplementation for Liver Disease (Acquired Hepatic Jaundice)

NCT07575789 | Completed

• 2 other identifiers: AZ786University of Lahore
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Jaundice is a frequent medical problem that affects people of all ages. It is important to note that jaundice is not an actual sickness as such itself but rather a symptom of liver illness brought on by an increase in the quantity of bilirubin circulating in the blood owing to improper metabolism and excretion in the urine. The aim of this investigation is to investigate the impact of grape (Vitis Vinifera) seed powder along with vitamin C supplementation on serum bilirubin levels in patients with acquired hepatic jaundice. In addition, it's the first research of its kind to investigate the aforementioned function of grape seed extract with vitamin C in healthy individuals specifically.

Conditions

Acquired Hepatic Jaundice

Keywords

Grape (VITIS VINIFERA) Seed Powder and Vitamin C

Outcome Measures

Primary Outcomes (1)

• Bilirubin levels

  In this study results showed the significant decrease in bilirubin levels in interventional group as compared to the conventional group

  4 weeks

Study Arms (2)

Conventional group

NO INTERVENTION

Control group

Intervention group

EXPERIMENTAL

Targeted group with intervention

Dietary Supplement: Grape-C supplement

Interventions

Grape-C supplement DIETARY_SUPPLEMENT

Grape-C supplement purchased from Nutrifactor brand.

Intervention group

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Both men and women
• Participants between the ages of 20-40 years will be included
• Patients having signs and symptoms of acquired hepatic jaundice
• Patients having high serum bilirubin, albumin, ALT, AST, ALP levels
• The patient having ALT level more than 10-50 U/L were included
• The participants having AST level above than 0-40 IU/L were included in this study
• Patients having ALP level more than 30 - 130 U/L were included in this research study
• Patients having level of bilirubin above than 0 - 21 μmol/L were included in this investigation
• Participants having the range of albumin more than 30-50 g/L were included in this research
• Participants those were underweighted were included

You may not qualify if:

• Patients who already taking any supplement or medication
• Participants taking any anti-inflammatory medications
• People who were suffering from any other disease
• Patients who have any known allergies
• Non willing patients
• Lactating women
• Pregnant women
• Smokers

Sponsors & Collaborators

• University of Lahore Hospital (ULH): lead

Study Sites (1)

University of Lahore

Lahore, Punjab Province, Pakistan

Location

Related Publications (1)

• DOI: 10.4103/1319-3767.65197

  BACKGROUND

Related Links

• Ghaffar, S., Naqvi, M. A., Fayyaz, A., Abid, M. K., Khayitov, K. N., Jalil, A. T., Alsaikhan, F., Hammid, A. T., Al-Gazally, M. E., \& Mohammadparast, V. (2022). What is the influence of grape products on liver enzymes? A systematic review and meta-ana
• Adikwu, E., \& Deo, O. (2013). Hepatoprotective effect of vitamin C (ascorbic acid)

Study Officials

• Dr Habib-ur-Rehman Rehman, PhD Food and Nutrition

  University of Lahore

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NETWORK
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Impact of Grape (VITIS VINIFERA) Seed Powder Along With Vitamin C Supplementation on Serum Bilirubin Levels in Patients With Acquired Hepatic Jaundice

Study Record Dates

• First Submitted: May 4, 2026
• First Posted: May 8, 2026
• Study Start: March 3, 2023
• Primary Completion: March 17, 2023
• Study Completion: April 4, 2023
• Last Updated: May 8, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)