Effect of High-Flow Nasal Oxygen on Laryngoscopic View

NCT07575776 | Not Yet Recruiting

• 1 other identifier: HFNORCT
• Study Type: observational
• Target: 150
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective, multicenter observational study aims to evaluate the effect of different flow rates of high-flow nasal oxygen (HFNO) on the quality of the laryngoscopic view during videolaryngoscopy in adult patients undergoing general anesthesia. Each patient will serve as their own control, with repeated measurements obtained at three different HFNO flow settings (0, 40, and 60 L/min). The study will assess objective and subjective parameters of glottic visualization using standardized scoring systems.

Conditions

High Flow Nasal Canula; Laryngoscopy; Airway Anesthesia; Airway Complication of Anaesthesia; Difficult Airway; Difficult / Failed Intubation

Keywords

high flow nasal canula; thrive; difficult airway; airway management; anaesthesia

Outcome Measures

Primary Outcomes (1)

• Quality of view

  Percentage of glottic opening (POGO score) assessed from recorded videolaryngoscopic images.

  From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).

Secondary Outcomes (2)

• Cormack-Lehane classification

  From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).

• Subjective image quality (Likert scale)

  From induction of general anesthesia to completion of orotracheal intubation (not longer than 10 minutes).

Study Arms (1)

Group HFNO

Adult patients with HFNO support for airway management

Device: HFNO flow 0; Device: HFNO flow 40; Device: HFNO 60

Interventions

HFNO flow 0 DEVICE

Different flows will be applied to patients undergoing general anaesthesia during airway management. In this arm flow will be 0 l/min. During these flows images will be captured using videolaryngoscope.

Group HFNO

HFNO flow 40 DEVICE

Different flows will be applied to patients undergoing general anaesthesia during airway management. In this arm flow will 40 l/min. During these flows images will be captured using videolaryngoscope.

Group HFNO

HFNO 60 DEVICE

Different flows will be applied to patients undergoing general anaesthesia during airway management. In this arm flow will 60 l/min. During these flows images will be captured using videolaryngoscope.

Group HFNO

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing elective surgical procedures requiring endotracheal intubation under general anesthesia.

You may qualify if:

• Age ≥18 years
• Scheduled for endotracheal intubation under general anesthesia
• Use of videolaryngoscopy

You may not qualify if:

• Anticipated difficult airway
• Emergency intubation
• Contraindications to HFNO
• Inability to obtain adequate video recording

Sponsors & Collaborators

• Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.: lead

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy for science and research

Study Record Dates

• First Submitted: May 4, 2026
• First Posted: May 8, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: May 8, 2026

Record last verified: 2026-05