Estimation of Fetal Weight by Measuring Abdominal Circumference, Abdominal Subcutaneous Soft Tissue Thickness, Femur Length and Mid-thigh Soft Tissue Thickness: Cross Sectional Study.

NCT07575152 | Not Yet Recruiting

• 1 other identifier: AssiutFetalWT
• Study Type: observational
• Target: 300
• Locations: 0 countries
• Sites: N/A

Brief Summary

Traditional methods for estimating fetal weight (EFW) often miss the mark because they focus on bone and circumference while ignoring fetal fat. This study proposes a more inclusive formula to fix that. Current models (using BPD, HC, AC, and FL) are the standard but suffer from high observer variability. These formulas struggle at the extremes (macrosomia or growth restriction) and fail to account for fetal adiposity, which makes up 10-12% of a newborn's mass. The study introduces a novel formula that moves beyond simple bone measurements by integrating Soft Tissue Thickness (STT). By accounting for a broader range of biological variants and fat distribution, this new model aims to provide a non-inferior, more precise predictive value for fetal weight compared to traditional methods.

Conditions

Using Fetal Soft Tissue Measurments With Traditonal Measurements for Fetal Weight Estimation

Keywords

fetal weight estimation; fetal soft tissue thickness; Macrosomia; fetal growth restriction; mid-thigh soft tissue thickness; fetal abdominal soft tissue thickness

Outcome Measures

Primary Outcomes (1)

• development and validation of novel method for fetal weight estimation

  a novel module for fetal weight estimation depending on abdominal circumference, fetal abdominal subcutaneous soft tissue thickness, femur length, mid-thigh soft tissue thickness.

  within 48- 72 hours of delivery

Study Arms (1)

Full term pregnant women

full term pregnant women with in 48-72 hours of delivery either cesarean section, spontaneous vaginal delivery or induced vaginal delivery.

Other: 3rd trimester ultrasound examination within 48-72 hours of delivery

Interventions

3rd trimester ultrasound examination within 48-72 hours of delivery OTHER

ultrasound examination of full-term pregnant women with 48-72 hours of delivery measuring Abdominal circumference, fetal abdominal subcutaneous soft tissue thickness, femur length and mid-thigh soft tissue thickness.

Full term pregnant women

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: full term pregnant females
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

full term pregnant women within 48-72 hours before delivery

You may qualify if:

• Singleton Gestation.
• Gestational Age: Participants must be at a term ≥ 37 weeks
• Timing of Examination: Sonographic EFW must be performed within 48 -72 hours prior to delivery.
• Welling to share in the study.

You may not qualify if:

• Fetal Anomalies.
• Amniotic Fluid Disorders: oligohydramnios or polyhydramnios
• Maternal morbid obesity (BMI \> 40 kg/m2)
• Maternal medical disorders: as diabetes, hypertension, systemic lupus erythromatosis or others affecting fetal growth
• Fetal Hydrops
• Fetal Malpresentation
• Fetal growth restriction

Sponsors & Collaborators

• Assiut University: lead

Related Publications (13)

• Paydary K, Seraj SM, Zadeh MZ, Emamzadehfard S, Shamchi SP, Gholami S, Werner TJ, Alavi A. The Evolving Role of FDG-PET/CT in the Diagnosis, Staging, and Treatment of Breast Cancer. Mol Imaging Biol. 2019 Feb;21(1):1-10. doi: 10.1007/s11307-018-1181-3.

  PMID: 29516387 BACKGROUND

• Deter RL. Individualized growth assessment: evaluation of growth using each fetus as its own control. Semin Perinatol. 2004 Feb;28(1):23-32. doi: 10.1053/j.semperi.2003.10.011.

  PMID: 15058899 BACKGROUND

• Scioscia M, Scioscia F, Vimercati A, Caradonna F, Nardelli C, Pinto LR, Selvaggi LE. Estimation of fetal weight by measurement of fetal thigh soft-tissue thickness in the late third trimester. Ultrasound Obstet Gynecol. 2008 Mar;31(3):314-20. doi: 10.1002/uog.5253.

  PMID: 18307214 BACKGROUND

• Lee W, Deter RL, McNie B, Goncalves LF, Espinoza J, Chaiworapongsa T, Romero R. Individualized growth assessment of fetal soft tissue using fractional thigh volume. Ultrasound Obstet Gynecol. 2004 Dec;24(7):766-74. doi: 10.1002/uog.1779.

  PMID: 15586365 BACKGROUND

• Lee W, Deter RL, McNie B, Goncalves LF, Espinoza J, Chaiworapongsa T, Balasubramaniam M, Romero R. The fetal arm: individualized growth assessment in normal pregnancies. J Ultrasound Med. 2005 Jun;24(6):817-28.

  PMID: 15914686 BACKGROUND

• Larciprete G, Di Pierro G, Barbati G, Deaibess T, Jarvis S, Valensise H, Romanini ME, Gioia S, Arduini D. Could birthweight prediction models be improved by adding fetal subcutaneous tissue thickness? J Obstet Gynaecol Res. 2008 Feb;34(1):18-26. doi: 10.1111/j.1447-0756.2007.00741.x.

  PMID: 18226124 BACKGROUND

• Bernstein IM, Goran MI, Amini SB, Catalano PM. Differential growth of fetal tissues during the second half of pregnancy. Am J Obstet Gynecol. 1997 Jan;176(1 Pt 1):28-32. doi: 10.1016/s0002-9378(97)80006-3.

  PMID: 9024084 BACKGROUND

• Galan HL, Rigano S, Radaelli T, Cetin I, Bozzo M, Chyu J, Hobbins JC, Ferrazzi E. Reduction of subcutaneous mass, but not lean mass, in normal fetuses in Denver, Colorado. Am J Obstet Gynecol. 2001 Oct;185(4):839-44. doi: 10.1067/mob.2001.117350.

  PMID: 11641662 BACKGROUND

• Skovron ML, Berkowitz GS, Lapinski RH, Kim JM, Chitkara U. Evaluation of early third-trimester ultrasound screening for intrauterine growth retardation. J Ultrasound Med. 1991 Mar;10(3):153-9. doi: 10.7863/jum.1991.10.3.153.

  PMID: 2027188 BACKGROUND

• Chang TC, Robson SC, Boys RJ, Spencer JA. Prediction of the small for gestational age infant: which ultrasonic measurement is best? Obstet Gynecol. 1992 Dec;80(6):1030-8.

  PMID: 1448248 BACKGROUND

• Kurmanavicius J, Burkhardt T, Wisser J, Huch R. Ultrasonographic fetal weight estimation: accuracy of formulas and accuracy of examiners by birth weight from 500 to 5000 g. J Perinat Med. 2004;32(2):155-61. doi: 10.1515/JPM.2004.028.

  PMID: 15085892 BACKGROUND

• Dudley NJ. A systematic review of the ultrasound estimation of fetal weight. Ultrasound Obstet Gynecol. 2005 Jan;25(1):80-9. doi: 10.1002/uog.1751.

  PMID: 15505877 BACKGROUND

• Rosati P, Exacoustos C, Caruso A, Mancuso S. Ultrasound diagnosis of fetal macrosomia. Ultrasound Obstet Gynecol. 1992 Jan 1;2(1):23-9. doi: 10.1046/j.1469-0705.1992.02010023.x.

  PMID: 12797002 BACKGROUND

MeSH Terms

Conditions

Fetal Growth Retardation

Interventions

Parturition

Condition Hierarchy (Ancestors)

Fetal Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Growth Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Pregnancy; Reproduction; Reproductive Physiological Phenomena; Reproductive and Urinary Physiological Phenomena

Central Study Contacts

Khaled Mustafa Attyia, Master's degree

CONTACT

+201005503250; khaled.hussien@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: May 4, 2026
• First Posted: May 8, 2026
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): December 30, 2027
• Study Completion (Estimated): July 30, 2028
• Last Updated: May 8, 2026

Record last verified: 2026-05