BPTB Versus Hamstring Autografts in ACL Reconstruction Among Professional Athletes

NCT07573293 | Completed

• 1 other identifier: N-360-2017
• Study Type: interventional
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective randomized controlled study compares outcomes of ACL reconstruction using bone-patellar tendon-bone (BPTB) versus hamstring tendon (HT) autografts in professional athletes. The primary outcome is isokinetic muscle strength assessment. Secondary outcomes include IKDC score, return to athletic activity, and complication rates. Patients are followed for five years.

Conditions

Anterior Cruciate Ligament Injury

Keywords

ACL reconstruction; Return to sport; Isokinetic muscle strength; BPTB autograft; Hamstring tendon autograft; Professional athletes

Outcome Measures

Primary Outcomes (1)

• Isokinetic Quadriceps and Hamstring Muscle Strength

  Isokinetic dynamometric assessment of quadriceps and hamstring muscle strength expressed as peak torque percentage relative to the contralateral limb using a standardized testing protocol.

  12 months postoperatively

Secondary Outcomes (4)

• International Knee Documentation Committee (IKDC) Score

  12 months postoperatively

• Time to Return to Athletic Activity

  Up to 12 months postoperatively

• Postoperative Complications

  Up to 60 months postoperatively

• Knee function using KOOS score

  60 months postoperatively

Study Arms (2)

BPTB Group

EXPERIMENTAL

Participants undergoing ACL reconstruction using bone-patellar tendon-bone (BPTB) autograft.

Procedure: BPTB ACL Reconstruction

Hamstring Group

ACTIVE COMPARATOR

Participants undergoing ACL reconstruction using hamstring tendon autograft (semitendinosus and gracilis).

Procedure: Hamstring ACL Reconstruction

Interventions

BPTB ACL Reconstruction PROCEDURE

Arthroscopic anterior cruciate ligament reconstruction using bone-patellar tendon-bone autograft with interference screw fixation.

BPTB Group

Hamstring ACL Reconstruction PROCEDURE

Arthroscopic anterior cruciate ligament reconstruction using semitendinosus and gracilis tendon autograft with appropriate fixation technique.

Hamstring Group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Professional athletes actively engaged in competitive sports
• Age between 18 and 35 years
• Primary isolated anterior cruciate ligament (ACL) rupture confirmed clinically and by MRI
• Indicated for arthroscopic ACL reconstruction
• Willingness to participate and provide informed consent

You may not qualify if:

• Multiligamentous knee injuries
• Previous ACL reconstruction on the affected knee
• Lower limb malalignment
• Advanced chondral lesions requiring additional surgical procedures
• Associated fractures around the knee
• Inability to comply with follow-up protocol

Sponsors & Collaborators

• Cairo University: lead
• Kasr Al-Ainy Hospitals: collaborator

Study Sites (1)

Kasr Al-Ainy Hospital, Cairo University

Cairo, Cairo Governorate, Egypt

Location

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries

Condition Hierarchy (Ancestors)

Knee Injuries; Leg Injuries; Wounds and Injuries

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Orthopedic Surgery

Model Details: Participants were randomly assigned to two parallel groups undergoing ACL reconstruction using either BPTB or hamstring tendon autografts.

Study Record Dates

• First Submitted: April 30, 2026
• First Posted: May 7, 2026
• Study Start: February 1, 2018
• Primary Completion: June 30, 2025
• Study Completion: June 30, 2025
• Last Updated: May 7, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)