A Study Of Acute Decompensated Heart Failure

NCT07572955 | Not Yet Recruiting

• 1 other identifier: 26-000119
• Study Type: interventional
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine shorter hospitalization length as well as a reduced rates of recurrent heart failure hospitalization compared to current standard of care in Acute Decompensated Heart Failure. A 1-day reduction in hospital length of stay in unblinded subjects receiving daily HF-FOCUS examinations compared to a blinded standard of care arm.

Conditions

Acute Decompensated Heart Failure

Outcome Measures

Primary Outcomes (1)

• Number of days in the hospital

  The number of days a patient is in the hospital will be determined by the day of admission and day of discharge. The day of discharge will be defined as when the consultant physician states that the patient is medically ready for discharge from the hospital.

  Baseline

Secondary Outcomes (5)

• Number of re-hospitalized patients

  Baseline

• Number of deaths

  Baseline

• Change in effective diuresis

  Baseline, up to 90 Days

• Change in diuretic dosing

  Baseline, up to 90 Days

• Change in Lung Congestion

  Baseline, up to 90 Days

Study Arms (2)

Group 1

ACTIVE COMPARATOR

Patients undergoing daily lung ultrasound with the results reported to the provider care teams on admission and each morning

Diagnostic Test: Lung Ultrasound

Group 2

EXPERIMENTAL

Patients undergoing daily lung ultrasound but the results will be blinded to the provider care teams

Diagnostic Test: Lung Ultrasound

Interventions

Lung Ultrasound DIAGNOSTIC_TEST

Patients will undergo lung ultrasound assessments at hospital admission, daily throughout admission, and at hospital discharge.

Group 1; Group 2

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects ≥18 years of age
• Admitted to St. Mary's Hospital Cardiology Progressive Care Unit (Cardiology 1-5 teams)
• Admission diagnosis of either:
• Acute systolic heart failure
• Acute on chronic systolic heart failure
• Acute diastolic heart failure
• Acute on chronic diastolic heart failure
• Acute right heart failure
• Acute on chronic right heart failure
• Failure heart biventricular
• Able to provide informed consent and willing to undergo daily lung ultrasound examinations during their hospitalization.

You may not qualify if:

• Subjects \<18 years of age
• Unable to provide informed consent.
• Unwilling to undergo daily lung ultrasound examinations.

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location

Study Officials

• Jared Bird, MD

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Andy Dang

CONTACT

507-255-7752; dang.phong@mayo.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 1, 2026
• First Posted: May 7, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): June 1, 2028
• Study Completion (Estimated): June 1, 2028
• Last Updated: May 7, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)