Development and Preliminary Validation of a Perioperative Pulmonary Rehabilitation Nursing System for Patients With Craniocerebral Tumors

NCT07571759 | Completed

• 1 other identifier: No. 2026-KY030-01
• Study Type: interventional
• Target: 165
• Locations: 1 country
• Sites: 1

Brief Summary

Title of Study: A New Nursing System to Help Lung Recovery After Brain Tumor Surgery Why was this study done? After surgery for a brain tumor (craniocerebral tumor), some patients develop lung problems like pneumonia or collapsed lung areas (atelectasis). These problems can slow down recovery, keep patients in the hospital longer, and make them feel worse. Doctors and nurses wanted to find a better way to protect the lungs and help patients breathe easier after surgery. What did the researchers want to find out? They wanted to see if a special, step-by-step nursing system for lung recovery-called the Perioperative Pulmonary Rehabilitation Nursing System (PPRNS) -could reduce lung problems after brain tumor surgery and help patients get back on their feet faster. What was done in the study? Who: 165 patients having brain tumor surgery at one hospital. How: Patients were put into two groups by chance (like flipping a coin): Control group (81 patients): Received regular, standard care after surgery. Intervention group (84 patients): Received the new PPRNS care. This included: Before surgery: Breathing exercises, learning to cough effectively, and nutrition advice. During surgery: Lung-protective methods by the anesthesia team. After surgery: Deep breathing exercises, sitting up and moving early, help clearing mucus from the lungs, and close monitoring. What was measured: The main thing measured was how many patients developed lung problems (like pneumonia) within 14 days after surgery. They also checked lung function, how fast patients recovered (walking, eating, removing tubes), length of hospital stay, and patient satisfaction. What were the main results? Fewer lung problems: Only 4.8% of patients in the new care group developed lung complications, compared to 13.6% in the regular care group. This means the new system cut lung problems by more than half. Better breathing: Patients in the new care group had stronger lung function tests (FVC, PEF) and higher oxygen levels after surgery. Faster recovery: They got off breathing tubes earlier, started walking sooner, cou

Conditions

Craniocerebral Tumors

Outcome Measures

Primary Outcomes (1)

• Incidence of Postoperative Pulmonary Complications (PPCs)

  Description: The occurrence of respiratory system-related complications, including but not limited to: Pneumonia (diagnosed based on clinical symptoms, laboratory findings, and radiographic evidence: fever, purulent sputum, pulmonary rales, new infiltrates on chest X-ray or CT) Atelectasis (confirmed radiographically) Severe hypoxemia requiring intervention Airway spasm Aspiration

  Within 14 days post-surgery

Secondary Outcomes (13)

• Forced Vital Capacity (FVC)

  Preoperative, postoperative day 1, and postoperative day 14 (or hospital discharge)

• Recovery Metrics (Functional Recovery Indicators)

  From surgery end until achievement (measured in hours or days)

• Postoperative Length of Hospital Stay

  At hospital discharge, assessed through study completion (average of 14 days)

• Incidence of Other (Non-Pulmonary) Complications

  Within 14 days post-surgery

• Postoperative Length of Hospital Stay

  At hospital discharge, assessed through study completion (average of 14 days post-surgery)

Other Outcomes (1)

• Safety / Adverse Events

  Within 14 days post-surgery

Study Arms (2)

The intervention group

EXPERIMENTAL

Behavioral: intervention group

The control group

NO INTERVENTION

Interventions

intervention group BEHAVIORAL

The intervention group received a comprehensive PPRNS, including preoperative respiratory training, postoperative exercises, early mobilization, and multidisciplinary care.

The intervention group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 to 75 years, inclusive
• Preoperative diagnosis of intracranial tumor confirmed by imaging and/or pathology per WHO Classification of Tumours of the Central Nervous System (5th edition), with planned craniotomy for tumor resection (initial or recurrent surgery)
• Preoperative assessment confirms ability to cooperate with pulmonary rehabilitation training (adequate consciousness, cognition, and communication for short-term training)
• Voluntary participation with written informed consent

You may not qualify if:

• Pre-existing severe chronic obstructive pulmonary disease (COPD GOLD stages 3-4)
• Pre-existing severe interstitial lung disease
• Requirement for long-term oxygen therapy
• Pneumonia or respiratory failure requiring mechanical ventilation within one month prior to surgery
• Severe cardiac dysfunction (New York Heart Association class III-IV)
• Other major organ insufficiency
• Severe impairment of consciousness
• Inability to follow commands
• Language barriers
• Life expectancy less than 30 days
• Concurrent participation in other interventional studies that could confound pulmonary function outcomes

Sponsors & Collaborators

• The Affiliated Brain Hospital of Nanjing Medical University: lead

Study Sites (1)

The Affiliated Brain Hospital of Nanjing Medical University

Nanjing, Jiangsu, 210029, China

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 14, 2026
• First Posted: May 6, 2026
• Study Start: February 5, 2025
• Primary Completion: December 7, 2025
• Study Completion: December 16, 2025
• Last Updated: May 6, 2026

Record last verified: 2026-04

Locations

CN (1)