Median Nerve Electromyography to Monitor Intraoperative Neuromuscular Function

NCT07571395 | Not Yet Recruiting DMC

• 1 other identifier: AITT 2026/1
• Study Type: observational
• Target: 45
• Locations: 0 countries
• Sites: N/A

Brief Summary

The effect of muscle relaxants need to be followed during surgery and before waking up the patient, the anesthesiologist has to make sure that the effect of muscle relaxants is gone. For this purpose, anesthesiologists use so called objective neurlmuscular monitors. These monitors stimulate the ulnar nerve in the wrist and examine the evoked muscle response. The aim of this study is to examine the usability of another nerve in the wrist, the median nerve.

Conditions

Nerve Conduction Study; Elective Surgery; Neuromuscular Monitoring After Administration of Neuromuscular Blocking Agents in Different Types of Surgery

Keywords

electromyography; neuromuscular blockade monitoring; median nerve

Outcome Measures

Primary Outcomes (1)

• CMAP

  Comparison of compound muscle action potential amplitudes evoked by median and ulnar nerve stimulation and measured at the thenar

  Baseline

Secondary Outcomes (2)

• Recovery time

  Perioperative

• Onset time

  Baseline

Other Outcomes (5)

• Bland-Altman analysis of TOFRs

  Intraoperative

• Bland-Altman analysis of TOFCs

  Intraoperative

• Bland-Altman analysis of PTCs

  Intraoperative

Study Arms (2)

Median nerve examination

Median nerves in the dominant and non-dominant hands are are examined

Diagnostic Test: Electromyography

Ulnar nerve examination

Ulnar nerves in the dominant and non-dominant hands are examined

Diagnostic Test: Electromyography

Interventions

Electromyography DIAGNOSTIC_TEST

Electromyographic examination of the median and ulnar nerves to monitor intraoperative neuromuscular blockade

Median nerve examination; Ulnar nerve examination

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing elective surgery that requires one dose of non-depolarising neuromuscular blocking agent, whose arms are accessible for intraoperative neuromuscular blockade monitoring.

You may qualify if:

• ASA I-III physical status
• elective surgery requiring muscle relaxation
• both arms are available during surgery in the same position for neuromuscular blockade monitoring
• signed informed consent form

You may not qualify if:

• neruomuscular disorder in patient history (eg. stroke, myasthenia)
• innervation problem in either arms (eg. carpal tunnel syndrome)
• deformity to either arms (eg. Dupyurten contracture, severe arthritis)
• Severe hepatic or renal insufficiency that affects muscle relaxant pharmacokinetics
• skin lesions at the site of electrode placement
• implanted pacemaker jelenléte
• gravidity
• muscle relaxant needs to be repeated during surgery

Sponsors & Collaborators

• Pongrácz Adrienn: lead

MeSH Terms

Interventions

Electromyography

Intervention Hierarchy (Ancestors)

Electrodiagnosis; Diagnostic Techniques and Procedures; Diagnosis; Myography

Central Study Contacts

Reka Nemes, MD PhD

CONTACT

+36 30 966 8722; nemes.reka@med.unideb.hu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 21, 2026
• First Posted: May 6, 2026
• Study Start: April 27, 2026
• Primary Completion (Estimated): March 31, 2028
• Study Completion (Estimated): March 31, 2028
• Last Updated: May 6, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share