Mucosal and Nasal Involvement and Their Correlation With Smell and Taste Functions in Lichen Planus Patients

NCT07570706 | Completed

• 2 other identifiers: LP-Nasal-2026-01LP-NOSE
• Study Type: observational
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates smell and taste function in patients diagnosed with lichen planus, a chronic inflammatory condition affecting the skin and mucous membranes. Adults aged 18-65 with lichen planus participated in taste and smell tests. Oral and nasal examinations were performed to check for mucosal involvement, and nasal endoscopy was used to further evaluate nasal involvement. A healthy control group of similar age also underwent taste and smell tests to compare results with the lichen planus patients. The study aims to better understand how lichen planus affects smell and taste, which may help improve patient care. Participation is voluntary, and all information collected will be kept confidential.

Conditions

Lichen Planus

Keywords

Lichen Planus; Taste Function; Smell Function; Olfactory Testing; Gustatory Testing; Nasal Endoscopy; Oral Mucosa; Nasal Mucosa; Mucosal Involvement; Healthy Controls

Outcome Measures

Primary Outcomes (2)

• Smell and Taste Function

  Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function. Time Frame: Single visit assessment

  Day 1

• Smell and taste function in patients with lichen planus

  Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function.

  Day 1

Study Arms (2)

Group 1- Lichen Planus Patients

Participants undergo taste and smell testing, oral and nasal examinations, and nasal endoscopy to assess mucosal involvement.

Other: Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess

Group 2 - Healthy Controls

Participants undergo taste and smell testing to provide comparative data with the lichen planus group.

Other: Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess

Interventions

Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess OTHER

Group 1 - Lichen Planus Patients: Participants undergo taste and smell testing to assess sensory function, oral and nasal examinations to evaluate mucosal involvement, and nasal endoscopy for detailed nasal assessment. Group 2 - Healthy Controls: Participants undergo taste and smell testing to provide comparative data for the lichen planus group.

Group 1- Lichen Planus Patients; Group 2 - Healthy Controls

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study includes adults aged 18-65 years with a clinical diagnosis of lichen planus, as well as healthy volunteers without lichen planus. Participants were assessed for smell and taste function, and the patient group also underwent oral and nasal mucosal examinations, including nasal endoscopy. Both male and female participants were included.

You may qualify if:

• Age 18-65 years Clinically diagnosed with lichen planus (patient group) Healthy individuals without lichen planus (control group) Willing and able to provide informed consent

You may not qualify if:

• Nasal septum deviation Nasal polyposis, congenital olfactory dysfunction, chronic rhinosinusitis, or allergic rhinitis History of head trauma History of nasal or paranasal surgery Psychiatric or neurological disorders (e.g., Parkinson's disease, Alzheimer's disease) Persistent loss of smell following COVID-19 infection Pregnancy or breastfeeding

Sponsors & Collaborators

• Istanbul Training and Research Hospital: lead

Study Sites (1)

S.B.U. Istanbul Training and Research Hospital

Istanbul, Istanbul, 34098, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Lichen Planus

Condition Hierarchy (Ancestors)

Lichenoid Eruptions; Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Yasemin Bolat Eren, MD

  S.B.U. Istanbul Eğitim ve Araştırma Hastanesi, Dermatology Department

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: April 9, 2026
• First Posted: May 6, 2026
• Study Start: January 1, 2026
• Primary Completion: March 20, 2026
• Study Completion: April 2, 2026
• Last Updated: May 6, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)