TREMOR IN CHARCOT-MARIE-TOOTH

NCT07570459 | Recruiting

• 1 other identifier: 17/05/2024_C3
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Tremor is a symptom that has already been described in many case reports and case series concerning patients with Charcot-Marie-Tooth (CMT) disease. However, the pathophysiology of tremor in this condition remains largely unclear. It has also not been sufficiently investigated to what extent tremor in CMT patients constitutes a relevant impairment of quality of life. This project focuses on a more detailed characterization of tremor in CMT patients using surface electromyography and accelerometer analysis, as well as the collection of individual clinical data, particularly regarding the symptom of tremor, in order to facilitate the characterization and etiological classification of the tremor. In addition, a questionnaire-based assessment will be conducted to capture the impact of tremor on activities of daily living and the associated burden in this specific patient cohort. The entire data collection process will be supported by a clinical examination, which will be video-recorded by experienced neurologists to ensure more reliable analysis. This serves both the characterization of tremor and the illustration of its functional limitations. Where available, the data will be correlated with genetic variants to allow conclusions about possible genetic predispositions or disease progression. As a control group, CMT patients who have not yet reported a tremor will be included.

Conditions

CMT; CMT (Charcot Marie Tooth Disease); Charcot Marie Tooth Disease (CMT); Charcot Marie Tooth Disease

Keywords

Tremor in CMT

Outcome Measures

Primary Outcomes (4)

• Activities of Daily Living -Questionaire(ADL)

  baseline

• Assessment of Handicap - Questionaire

  baseline

• Fahn Tolosa Marin Rating Scale

  baseline

• Electrophysiological characterization of tremor using surface EMG and accelerometer analysis

  baseline

Secondary Outcomes (2)

• MDS-UPDRS Part III without Tremor

  baseline

• SARA Score

  baseline

Study Arms (2)

CMT patients

Controls

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

CMT-patients and healthy controls

You may qualify if:

• Clinical CMT Diagnosis / Anamnestically Healthy Control Group
• Genetic confirmation of CMT in adult patients
• Ability to achieve the outcome measure at baseline
• Age between 18 and 65 years
• Capacity of all study participants to consent and signed informed consent, including patient or participant information and consent form

You may not qualify if:

• Pregnancy or breastfeeding period
• Other relevant neurological or psychiatric disorders, acute or in the past history
• Presence of a serious previous internal disease

Sponsors & Collaborators

• University Medical Center Goettingen: lead

Study Sites (1)

University Medical Centre

Göttingen, Lower Saxony, 37075, Germany

RECRUITING

MeSH Terms

Conditions

Charcot-Marie-Tooth Disease

Condition Hierarchy (Ancestors)

Hereditary Sensory and Motor Neuropathy; Nervous System Malformations; Nervous System Diseases; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Genetic Diseases, Inborn

Central Study Contacts

Michael W Sereda, Prof. MD

CONTACT

+49 551 3964162; sereda@mpinat.mpg.de

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Michael Sereda MD

Study Record Dates

• First Submitted: April 9, 2026
• First Posted: May 6, 2026
• Study Start: July 30, 2024
• Primary Completion (Estimated): July 5, 2026
• Study Completion (Estimated): October 30, 2026
• Last Updated: May 6, 2026

Record last verified: 2026-04

Locations

DE (1)