Enhancing Readability of Lay Abstracts and Summaries for Medical Knowledge Using Generative Artificial Intelligence (BRIDGE AI 3)

NCT07568444 | Completed Phase 2

• 1 other identifier: UP-24-01142
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This trial tests if AI can help make medical info clear and readable. Many patients struggle to find medical informations that easy to read and understand from verified medical sources. The study tests if an AI tool can assist health providers to craft clear text for patients more fast than what they do now. Health providers are split at random into two groups-one uses the AI tool and one does not. The trial tests how clear the text is, how correct it is, and how much time is saved. The aim is to see if AI can close the gap between complex research and what patients can grasp.

Conditions

Prostate Cancer (Adenocarcinoma); Bladder Cancer; Kidney Cancers; Testis Cancer

Keywords

Bridge AI; Generative Artificial Intelligence; GAI

Outcome Measures

Primary Outcomes (6)

• Readability Change

  Flesch Reading Ease Score Description: Measures text readability based on sentence length and word syllables. Scale: 0 to 100 Interpretation: Higher scores indicate easier readability (better outcome).

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

• Readability Change

  Flesch-Kincaid Grade Level Description: Estimates U.S. school grade level required to understand the text. Scale: Typically ranges from \~0 to 18+ Interpretation: Lower scores indicate easier readability (better outcome).

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

• Readability Change

  Gunning Fog Index Description: Estimates years of formal education needed to understand the text on first reading. Scale: Typically 0 to 20+ Interpretation: Lower scores indicate easier readability (better outcome).

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

• Readability Change

  SMOG Index (Simple Measure of Gobbledygook) Description: Estimates years of education required to comprehend the text. Scale: Typically 0 to 20+ Interpretation: Lower scores indicate easier readability (better outcome).

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

• Readability Change

  Coleman-Liau Index Description: Readability formula based on characters per word and sentence length. Scale: Typically 0 to 18+ (grade level equivalent) Interpretation: Lower scores indicate easier readability (better outcome).

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

• Readability Change

  Automated Readability Index (ARI) Description: Estimates grade level required for comprehension using characters and word counts. Scale: Typically 0 to 14+ Interpretation: Lower scores indicate easier readability (better outcome).

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

Secondary Outcomes (12)

• Time Saving

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

• Correctness and meaning retention

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

• Correctness and meaning retention

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

• Correctness and meaning retention

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

• Correctness and meaning retention

  The assessment will be conducted immediately after the study closes, which will occur 4 weeks after enrollment.

Study Arms (2)

Gold Standard

NO INTERVENTION

Pub2Post

EXPERIMENTAL

Other: Pub2Post

Interventions

Pub2Post OTHER

Pub2Post, a generative artificial intelligence agent which helps in drafting the layperson abstracts and summaries

Pub2Post

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Corresponding authors who have been published in the top 10 journals of urology and medicine
• All genders
• Any profession
• + years of age

You may not qualify if:

• Anyone under the age of 18
• Participants that have not published in the top 10 journals of urology and medicine

Sponsors & Collaborators

• University of Southern California: lead

Study Sites (1)

University of Southern California

Los Angeles, California, 91100, United States

Location

MeSH Terms

Conditions

Prostatic Neoplasms; Adenocarcinoma; Urinary Bladder Neoplasms; Kidney Neoplasms; Testicular Neoplasms

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Urologic Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urinary Bladder Diseases; Urologic Diseases; Kidney Diseases; Endocrine Gland Neoplasms; Endocrine System Diseases; Testicular Diseases; Gonadal Disorders

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Urology

Model Details: This is a parallel-group randomized controlled trial in which participants are assigned in a 1:1 ratio to either an AI-assisted intervention arm or a control arm using conventional methods. In the intervention arm, participants use a generative AI tool to produce lay summaries from scientific abstracts. In the control arm, participants generate lay summaries without AI assistance. Outcomes are assessed post-task for each participant. No crossover between arms is planned.

Study Record Dates

• First Submitted: March 12, 2025
• First Posted: May 5, 2026
• Study Start: January 16, 2025
• Primary Completion: January 22, 2025
• Study Completion: February 27, 2025
• Last Updated: May 6, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP

Locations

US (1)