Increasing Lung Cancer Screening Among Emergency Department Patients - LCS R01

NCT07566221 | Not Yet Recruiting

• 1 other identifier: FP00007604
• Study Type: interventional
• Target: 1,036
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomized clinical trial evaluates the effectiveness of text messaging and facilitated referral strategies to increase lung cancer screening uptake among emergency department patients who meet lung cancer screening eligibility criteria.

Conditions

Smoking History; Current Smoker; Lung Cancer Screening

Keywords

Lung Cancer Screening; Emergency Department; Smoking

Outcome Measures

Primary Outcomes (1)

• Proportion of Participants Who Complete Lung Cancer Screening Within 120 Days After Enrollment

  Lung cancer screening uptake is defined as completion of a low dose computed tomography scan for lung cancer screening within 120 days after enrollment. Screening completion will be confirmed using electronic health record review, lung cancer screening program records, or participant self report obtained during follow up. The outcome is reported as the proportion of participants who complete screening.

  Up to 120 Days After Enrollment

Secondary Outcomes (5)

• Proportion of Participants Who Participate in Shared Decision Making for Lung Cancer Screening Within 120 Days After Enrollment

  Up to 120 Days After Enrollment

• Frequency of Reported Barriers to Lung Cancer Screening at 120 Days

  120 Days After Enrollment

• Acceptability of Emergency Department Based Lung Cancer Screening Interventions at 120 Days

  Up to 120 Days After Enrollment

• Appropriateness of Emergency Department Based Lung Cancer Screening Interventions at 120 Days

  120 Days After Enrollment

• Frequency of Reported Facilitators to Lung Cancer Screening at 120 Days

  120 Days After Enrollment

Study Arms (4)

Basic Referral (enhanced control arm)

ACTIVE COMPARATOR

Participants assigned to this arm will be notified that they are eligible and meet federal recommendations for lung cancer screening. They will be verbally referred to a lung cancer screening program and their primary care provider (if they have one) to discuss lung cancer screening. They will also be provided with written materials that include telephone contact information for the lung cancer screening program navigator. If contacted, the LCS Program Navigator will conduct a discussion, schedule a screening CT scan at one of the 8 regional American College of Radiology-designated lung cancer screening centers and arrange clinical follow-up as needed.

Behavioral: Basic Referral

Basic Referral plus Text Messaging

EXPERIMENTAL

Participants assigned to this arm will receive the basic referral as described in the previous arm. In addition, they will receive a series of text messages, aimed at generating intention and motivation to get lung cancer screening. Patients will receive a total of 9 messages.

Behavioral: Basic Referral; Behavioral: Text Messaging

Facilitated Referral

ACTIVE COMPARATOR

Participants assigned to this arm will be notified that they are eligible and meet federal recommendations for lung cancer screening. Rather than the basic referral received in the arms above, a lung cancer screening requisition form will be submitted to the lung cancer screening program on behalf of the participant during their emergency department visit.

Behavioral: Facilitated Referral

Facilitated Referral plus Text Messaging

EXPERIMENTAL

Participants assigned to this arm will receive facilitated referral plus the series of text messages described above. Among these participants, contact with the lung cancer screening program is likely to occur after receipt of the initial text messages but prior to receipt of all text messages.

Behavioral: Facilitated Referral; Behavioral: Text Messaging

Interventions

Basic Referral BEHAVIORAL

Participants are verbally referred to the lung cancer screening program and their primary care provider if applicable. Written materials with contact information for the lung cancer screening program navigator are provided.

Basic Referral (enhanced control arm); Basic Referral plus Text Messaging

Facilitated Referral BEHAVIORAL

A lung cancer screening requisition form is submitted to the lung cancer screening program on behalf of the participant during the emergency department visit. The screening program will contact the participant to discuss screening and schedule a low dose CT scan if appropriate.

Facilitated Referral; Facilitated Referral plus Text Messaging

Text Messaging BEHAVIORAL

Participants receive a series of up to 9 theory informed text messages designed to increase awareness, motivation, and completion of lung cancer screening.

Basic Referral plus Text Messaging; Facilitated Referral plus Text Messaging

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 50 - 80
• ≥ 20 pack-year smoking history
• current smoker or quit within 15 years
• English/Spanish speaking
• Registered in the Emergency Department as a patient

You may not qualify if:

• Non-English/Spanish
• Inability to provide consent (e.g. high clinical acuity, cognitive deficit)
• Lack of text-capable mobile phone and/or inability to use text function

Sponsors & Collaborators

• University of Rochester: lead

MeSH Terms

Conditions

Emergencies; Smoking

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Behavior

Central Study Contacts

Peter Macdowell

CONTACT

585-274-1509; peter_macdowell@urmc.rochester.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 27, 2026
• First Posted: May 5, 2026
• Study Start (Estimated): March 1, 2027
• Primary Completion (Estimated): December 1, 2030
• Study Completion (Estimated): December 1, 2031
• Last Updated: May 5, 2026

Record last verified: 2026-04