Enhanced Recovery After Surgery in Hysterectomy Patients

NCT07564063 | Not Yet Recruiting

• 1 other identifier: MS-729-2025
• Study Type: interventional
• Target: 78
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective randomized controlled clinical trial aims to evaluate the effectiveness of Enhanced Recovery After Surgery (ERAS) protocols in patients undergoing elective hysterectomy. ERAS is an evidence-based perioperative approach designed to reduce surgical stress, accelerate recovery, and improve clinical outcomes. Participants will be randomized to receive either ERAS-based care or conventional perioperative management. The study will assess whether ERAS implementation reduces hospital stay and improves postoperative recovery without increasing complications.

Conditions

Enhanced Recovery After Surgery (ERAS) Protocol

Outcome Measures

Primary Outcomes (1)

• length of hospital stay (LOS)

  Time from completion of surgery to hospital discharge readiness, measured in days.

  From day of surgery up to 7 postoperative days

Secondary Outcomes (2)

• postoperative pain score

  At 12 and 24 hours postoperatively

• time to first bowel movement

  Up to 5 postoperative days

Study Arms (2)

ERAS group

ACTIVE COMPARATOR

Preoperative counseling Reduced fasting and carbohydrate loading Standardized anesthesia with reduced opioid use Early oral feeding Early mobilization Multimodal analgesia IV dextrose infusion (5%) 500 ml once or apple juice( 200-400 mL) 2-3 hours before anesthesia

Drug: dextrose (5%); Procedure: ERAS protocols

Conventional care

NO INTERVENTION

Overnight fasting Delayed postoperative feeding Opioid-based analgesia Delayed mobilization Routine prolonged use of drains/catheters

Interventions

dextrose (5%) DRUG

IV dextrose infusion (5%) 500 ml once ,2-3 hours before anesthesia

ERAS group

ERAS protocols PROCEDURE

Reduced fasting Early oral feeding Early mobilization

ERAS group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Women aged 18-70 years.
• Undergoing elective total hysterectomy for benign or early stage malignant gynacological conditions .
• ASA ( American Society of Anesthesiologists ) physical status I-II.
• Able to provide informed consent.

You may not qualify if:

• Emergency hysterectomy
• Advanced malignant requiring extensive debulking
• Known bowel disease or previous bowel surgery ( crohn's disease , bowel obstruction )
• Significant cognitive impairment or psychiatric illness
• Inability to follow ERAS protocol (e.g., cognitive impairment)
• Refusal to participate

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

faculty of medicine-Cairo university

Cairo, Egypt

Location

MeSH Terms

Interventions

Glucose

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Officials

• Ehab H Sorour, MD

  Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ehab H Sorour, MD

CONTACT

+201112496821; dr.ehabsorour@gmail.com

Mohamed E El Mahy, MD

CONTACT

+201111831716; mohammed.elmahy@kasralainy.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer

Study Record Dates

• First Submitted: April 26, 2026
• First Posted: May 4, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): January 1, 2027
• Last Updated: May 4, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)