Comparison Between Medial Patellofemoral Ligament Reconstruction Alone Versus Combined MPFL & Medial Patellotibial Ligament Reconstruction in the Management of Recurrent Lateral Patellar Dislocation in Children

NCT07564011 | Not Yet Recruiting

• 1 other identifier: MPFL-MPTL-2026-1
• Study Type: interventional
• Target: 22
• Locations: 0 countries
• Sites: N/A

Brief Summary

Patellofemoral instability (PFI) is a common condition that may result from numerous underlying soft tissue and bony abnormalities, and can significantly impact the patients' quality of life and function. It is estimated that PFI affects between 5.8 and 29 out of every 100,000 children aged 10 to 17 years \[1\]. Patellar instability is defined as a symptomatic deficiency of the passive constraint such that the patella may escape partially or completely from its anatomic position with respect to the femoral trochlea under the influence of a displacing force. Such a displacing force could be generated by muscle tension, movement, and/or externally applied forces \[2\]. The etiology of RPD is multifactorial, including medial patellofemoral ligament (MPFL) injuries, abnormally lateralized tibial tubercle (TT), femoral trochlear dysplasia, patella alta, increased femoral anteversion and genu valgum \[3,5\]. The MPFL is the primary static soft tissue restraint which restrains against lateral subluxation and dislocation of the patella, especially between 0° and 30° of knee flexion \[3\]. And the MPTL act as secondary restraint\[4.\] Therefore, injury or deficiency of MPFL is one of the predisposing factors for RPD.Therefore, an anatomical repair MPFL is necessary to prevent redislocation of patella \[6\]. MPFL reconstruction is widely recognized as an important component of the current treatment for recurrent patellar instability, MPTL reconstruction improve medial patellar stabilization, patellar tilt, patellar rotation as well as decreases stress on MPFL.A large number of surgical methods for treating patellofemoral instability have been described in various studies, but the best method is still controversial\[7\]. This study is prepared to compare the results of MPFL reconstruction versus combined MPFL and MPTL reconstruction in management of recurrent lateral patellar dislocation in children .

Conditions

Recurrent Patellar Displacement; MPFL

Keywords

MPFL reconstruction

Outcome Measures

Primary Outcomes (3)

• Kujala Score for knee function

  12 months post operative

• Lysholm score for knee function

  12 month

• Redislocation rate

  12 months

Secondary Outcomes (2)

• Range of motion

  12 month

• Complications

  12months

Study Arms (2)

MPFL Reconstruction For Recurrent patellar displacement in children

EXPERIMENTAL

MPFL reconstruction

Procedure: MPFL Reconstruction

Combined MPFL and MPTL for Recurrent patellar displacement in children

EXPERIMENTAL

MPFL +MPTL Reconstruction

Procedure: MPFL + MPTL Reconstruction

Interventions

MPFL Reconstruction PROCEDURE

Medial patellofemoral ligament reconstruction

MPFL Reconstruction For Recurrent patellar displacement in children

MPFL + MPTL Reconstruction PROCEDURE

Combined medial patellofemoral and mediopatellotibial ligaments reconstruction

Combined MPFL and MPTL for Recurrent patellar displacement in children

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Age : \<18years old.
• History of recurrent lateral patellar dislocation (\>2 episodes).
• Failure of conservative treatment. -

You may not qualify if:

• Active infection.
• inflammatory joint disorders.
• trochlear dysplasia
• previous surgeries related to patella dislocation -

Sponsors & Collaborators

• Assiut University: lead

Related Publications (7)

• Li YJ, Tang DX, Yan HT, Yang B, Yang Z, Long FX. Network pharmacology and molecular docking-based analyses to predict the potential mechanism of Huangqin decoction in treating colorectal cancer. World J Clin Cases. 2023 Jul 6;11(19):4553-4566. doi: 10.12998/wjcc.v11.i19.4553.

  PMID: 37469733 BACKGROUND

• Mueller K, Syed HR, Rhee JW, Nair MN. Delayed Chyle Leak Following Anterior Cervical Spinal Surgery: A Case Report and Management Algorithm. Cureus. 2017 May 9;9(5):e1231. doi: 10.7759/cureus.1231.

  PMID: 28620562 BACKGROUND

• Fu B, Shen J, Chen Y, Wu Y, Zhang H, Liu H, Huang W. Narrative review of gene modification: applications in three-dimensional (3D) bioprinting. Ann Transl Med. 2021 Oct;9(19):1502. doi: 10.21037/atm-21-2854.

  PMID: 34805364 BACKGROUND

• Felli L, Alessio-Mazzola M, Lovisolo S, Capello AG, Formica M, Maffulli N. Anatomy and biomechanics of the medial patellotibial ligament: A systematic review. Surgeon. 2021 Oct;19(5):e168-e174. doi: 10.1016/j.surge.2020.09.005. Epub 2020 Oct 26.

  PMID: 33121878 BACKGROUND

• Ng KT, Ng LJ, Oong XY, Chook JB, Chan KG, Takebe Y, Kamarulzaman A, Tee KK. Application of a VP4/VP2-inferred transmission clusters in estimating the impact of interventions on rhinovirus transmission. Virol J. 2022 Mar 4;19(1):36. doi: 10.1186/s12985-022-01762-w.

  PMID: 35246187 BACKGROUND

• Bere E, Lahbib K, Merceron B, Fleurat-Lessard P, Boughanmi NG. alpha-TIP aquaporin distribution and size tonoplast variation in storage cells of Vicia faba cotyledons at seed maturation and germination stages. J Plant Physiol. 2017 Sep;216:145-151. doi: 10.1016/j.jplph.2017.04.019. Epub 2017 Jun 1.

  PMID: 28641151 BACKGROUND

• Dejour DH, Mesnard G, Giovannetti de Sanctis E. Updated treatment guidelines for patellar instability: "un menu a la carte". J Exp Orthop. 2021 Nov 26;8(1):109. doi: 10.1186/s40634-021-00430-2. No abstract available.

  PMID: 34837157 BACKGROUND

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: April 19, 2026
• First Posted: May 4, 2026
• Study Start (Estimated): June 17, 2026
• Primary Completion (Estimated): March 17, 2028
• Study Completion (Estimated): June 17, 2028
• Last Updated: May 4, 2026

Record last verified: 2026-04