A Comparative Study of Preoperative Carbohydrate Loading Dose and Fasting on Postoperative Recovery Time in Elective Abdominal Surgery Patients

NCT07562776 | Not Yet Recruiting DMC

• 1 other identifier: RCT-ERAS-2026-01
• Study Type: interventional
• Target: 144
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomized controlled trial aims to compare the effect of preoperative carbohydrate loading versus standard overnight fasting on postoperative recovery time in patients undergoing elective abdominal surgery. A total of 144 admitted patients will be randomly assigned to either receive a preoperative carbohydrate drink or follow routine fasting protocols. The primary objective is to evaluate differences in postoperative recovery time between the two groups. Secondary outcomes include length of hospital stay, postoperative complications, and patient comfort. The findings of this study may help optimize preoperative fasting guidelines and improve patient recovery outcomes.

Conditions

This Study Mainly Focus on the Eras Protocol Decreasing Time of Npo and Early Discharge From Hospital to Avoid Hospital Acquired Infections

Keywords

ERAS protocol; Pre op carbohydrate loading dose; Less time of npo

Outcome Measures

Primary Outcomes (1)

• Post operative insuline resistance

  To evaluate the effect of preoperative oral carbohydrate loading compared with standard fasting on postoperative insulin resistance in patients undergoing elective abdominal surgery. Insulin resistance will be assessed by measuring fasting blood glucose and serum insulin levels preoperatively and postoperatively, and calculating insulin resistance using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).

  24 hours after surgery

Secondary Outcomes (1)

• Time to first oral intake

  24 hours after surgery

Study Arms (2)

Pre operative carbohydrate Loading group

EXPERIMENTAL

Patients in this group will receive a preoperative carbohydrate-rich clear liquid drink before elective abdominal surgery to reduce insulin resistance, improve postoperative recovery, and decrease discomfort associated with prolonged fasting.

Dietary Supplement: Patients will be given 400 mL of a carbohydrate-rich clear drink (10% daxtrosewater) approximately 2-3 hours before induction of anesthesia, according to ERAS guidelines.

Standard preoperative fasting group

ACTIVE COMPARATOR

Patients in this group will follow the routine preoperative fasting protocol as per hospital practice, including overnight fasting from solids and clear liquids according to standard anesthetic guidelines before elective abdominal surgery. No preoperative carbohydrate drink will be administered. Postoperative recovery outcomes will be compared with the intervention group receiving preoperative carbohydrate loading.

Other: Standard pre operative fasting

Interventions

Patients will be given 400 mL of a carbohydrate-rich clear drink (10% daxtrosewater) approximately 2-3 hours before induction of anesthesia, according to ERAS guidelines. DIETARY_SUPPLEMENT

Most previous studies have evaluated preoperative carbohydrate loading in mixed surgical populations or in settings outside Pakistan. Limited local data exist specifically for elective abdominal surgery patients in a single-center Pakistani tertiary care hospital setting. Thisstudy focuses on comparing a standardized carbohydrate loading dose with conventional fasting and assessing its direct impact on postoperative recovery time in your local population. surgery patients specifically It uses a standardized carbohydrate loading dose It compares against the routinely practiced prolonged fasting protocol It is conducted in a single-center local hospital population, where local evidence is limited It focuses on postoperative recovery time as the primary clinical outcome

Pre operative carbohydrate Loading group

Standard pre operative fasting OTHER

Patients in this group will follow the routine preoperative fasting protocol according to hospital and anesthesia guidelines, including overnight fasting from solids and clear liquids before elective abdominal surgery. No preoperative carbohydrate loading will be give

Standard preoperative fasting group

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 20-60
• ASA I-II classification.
• Elective open or laparoscopic abdominal surgeries.

You may not qualify if:

• Diabetes mellitus or impaired fasting glucose.
• Emergency surgeries.
• Patients with hepatic or renal dysfunction.
• Patients on corticosteroids or insulin-sensitizing agents.
• Pregnant patients.

Sponsors & Collaborators

• Gulab Devi Hospital: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Post graduate resident

Study Record Dates

• First Submitted: April 25, 2026
• First Posted: May 1, 2026
• Study Start (Estimated): October 1, 2026
• Primary Completion (Estimated): November 1, 2027
• Study Completion (Estimated): February 1, 2028
• Last Updated: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share