COmparison of Maintenance of Propofol And Sevoflurane Spectral Study
COMPASS
Comparison of EEG Power Spectrum During Maintenance of Anesthesia With Propofol Versus Sevoflurane
1 other identifier
interventional
280
1 country
1
Brief Summary
Lower EEG alpha band power is currently extensively studied as a potential biomarker of brain vulnerability. No previous study has evaluated whether there was a difference in EEG power spectrum ranges between propofol and sevoflurane, the two main anesthetic agents for maintenance of general anesthesia, in order to define a cut-off value for the prediction of a higher risk of postoperative delirium.
- Primary objective: comparison of EEG alpha power (dB) during maintenance of anesthesia with propofol and sevoflurane using data available in the NeuroSense® depth-of-anesthesia monitoring
- Secondary objectives: comparison of other EEG frequency bands during maintenance of anesthesia with propofol and sevoflurane using data from the NeuroSense® depth-of-anesthesia monitoring
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Apr 2026
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 13, 2026
CompletedFirst Submitted
Initial submission to the registry
April 17, 2026
CompletedFirst Posted
Study publicly available on registry
May 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2027
May 1, 2026
April 1, 2026
1.6 years
April 17, 2026
April 24, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Alpha-band power
Power in decibels from the NeuroWave monitor under general anesthesia
Intra-operative
Secondary Outcomes (3)
Delta-band power
Intra-operative
Thêta-band power
Intra-operative
Bêta-band power
Intra-operative
Study Arms (2)
Propofol maintenance
ACTIVE COMPARATORSevoflurane maintenance
EXPERIMENTALInterventions
Maintenance of general anesthesia for simple electrophysiological procedures
Maintenance of general anesthesia for simple electrophysiological procedures
Eligibility Criteria
You may qualify if:
- Capable to give informed consent
- French-speaking patients
You may not qualify if:
- Need for a premedication with benzodiazepine before anesthesia
- Reduced left ventricular ejection fraction (\< 50%) or underlying cardiac pathology requiring a more balanced anesthesia (administration of benzodiazepine and/or ketamine during anesthesia)
- Preoperative MoCA score \< 26/30 (for patients \> ou = 55 years old)
- Patients treated with anti-epileptic drugs
- Patients treated with benzodiazepines (ex: for anxiolysis or sleep disorders)
- Emergencies
- Morbid obesity (BMI \> 40kg/m2)
- Background of severe postoperative nausea/vomit
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Cliniques universitaires Saint-Luc
Brussels, 1200, Belgium
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 17, 2026
First Posted
May 1, 2026
Study Start
April 13, 2026
Primary Completion (Estimated)
December 1, 2027
Study Completion (Estimated)
December 1, 2027
Last Updated
May 1, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share